APCS and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 11359830)
0

Data Source:
HPRD (in vitro)

		APCS	FCGR1A
Description		amyloid P component, serum	Fc gamma receptor Ia
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding	Protein Binding IgG Receptor Activity High-affinity IgG Receptor Activity IgG Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process	Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Immune System Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Regulation Of Immune Response
Pathways		Amyloid fiber formation	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate	Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Blood protein levels ( 30072576) C-reactive protein ( 22939635) Neonatal white matter microstructure ( 33009551)
Interacting Genes		18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	31 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CLIC6 CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		325	2209
HPRD ID		00101	00904
Ensembl ID		ENSG00000132703	ENSG00000150337
Uniprot IDs		P02743 V9HWP0	P12314
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	3RJD 4W4O 4X4M 4ZNE 8DIN 8DIR 8DJ7
Enriched GO Terms of Interacting Partners?		IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent	Immune System Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Inflammatory Response Immune Effector Process Regulation Of Immune Response Leukocyte Degranulation Regulation Of Immune System Process Positive Regulation Of Monocyte Chemotactic Protein-1 Production Fc Receptor Signaling Pathway Immune Response Acute Inflammatory Response Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Positive Regulation Of Immune System Process Response To External Biotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Interleukin-8 Production Regulation Of Superoxide Metabolic Process Cellular Response To Molecule Of Fungal Origin Membrane Extracellular Region Fc-gamma Receptor Signaling Pathway Exocytosis Response To Molecule Of Fungal Origin Regulation Of Phagocytosis Regulated Exocytosis Plasma Membrane Acute-phase Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Complement Component C1q Complex Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Neutrophil Differentiation Response To Other Organism Positive Regulation Of Myeloid Cell Apoptotic Process Defense Response To Fungus Cell Activation Virion Binding Positive Regulation Of Immune Response Response To Fungus Positive Regulation Of Interleukin-8 Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Negative Regulation Of Inflammatory Response Defense Response To Symbiont
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