APCS

Description		amyloid P component, serum
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Amyloid fiber formation
Drugs		Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate
Diseases
GWAS		Blood protein levels ( 30072576) C-reactive protein ( 22939635) Neonatal white matter microstructure ( 33009551)
Interacting Genes		18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		325
HPRD ID		00101
Ensembl ID		ENSG00000132703
Uniprot IDs		P02743 V9HWP0
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent
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