APCS and LAMA1

Number of citations of the paper that reports this interaction (PMID 8999915)
8

Data Source:
HPRD (in vitro)

		APCS	LAMA1
Gene Name		amyloid P component, serum	laminin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Extracellular Matrix
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis
Pathways		Amyloids	Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions
Drugs		Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Diseases
GWAS		C-reactive protein ( 22939635)	Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455)
Protein-Protein Interactions		17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	19 interactors: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6
Entrez ID		325	284217
HPRD ID		00101	01033
Ensembl ID		ENSG00000132703	ENSG00000101680
Uniprot IDs		P02743	P25391
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway	Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cell-matrix Adhesion Regulation Of Body Fluid Levels Negative Regulation Of Wound Healing Wound Healing Cell-substrate Adhesion Extracellular Matrix Disassembly Cell Adhesion Fibrinolysis Regulation Of Inflammatory Response Locomotion Regulation Of Wound Healing Acute-phase Response Viral Entry Into Host Cell Chemotaxis Entry Into Host Cell Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Axon Guidance Negative Regulation Of Blood Coagulation Response To Stress Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Acute Inflammatory Response Leukocyte Migration Cell Migration Axonogenesis Cell Motility Cell Adhesion Mediated By Integrin Basement Membrane Organization Axon Development Positive Regulation Of Endocytosis Regulation Of Blood Coagulation Cell Morphogenesis Involved In Neuron Differentiation Interaction With Host Negative Regulation Of Inflammatory Response Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Formation Of Primary Germ Layer Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport
Tagcloud ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing
Tagcloud (Difference) ?		aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity	annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing
Tagcloud (Intersection) ?