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APCS and C4BPA
Number of citations of the paper that reports this interaction (PubMedID
7592941
)
0
Data Source:
HPRD
(in vitro)
APCS
C4BPA
Description
amyloid P component, serum
complement component 4 binding protein alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Plasma Membrane
Blood Microparticle
Molecular Function
Complement Component C1q Complex Binding
Calcium Ion Binding
Protein Binding
Carbohydrate Binding
Identical Protein Binding
Virion Binding
Metal Ion Binding
Unfolded Protein Binding
RNA Binding
Protein Binding
Biological Process
Negative Regulation Of Acute Inflammatory Response
Protein Folding
Acute-phase Response
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
Innate Immune Response
Negative Regulation Of Monocyte Differentiation
Host-mediated Suppression Of Symbiont Invasion
Negative Regulation Of Viral Process
Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Wound Healing
Negative Regulation Of Glycoprotein Metabolic Process
Immune System Process
T Cell Mediated Immunity
Complement Activation, Classical Pathway
Response To Symbiotic Bacterium
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Complement Activation, Classical Pathway
Regulation Of Immune Response
Response To Other Organism
Regulation Of Opsonization
Pathways
Amyloid fiber formation
Regulation of Complement cascade
Drugs
Zinc
Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside
Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane
BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Copper
Zinc acetate
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS
Blood protein levels (
30072576
)
C-reactive protein (
22939635
)
Neonatal white matter microstructure (
33009551
)
Bell's palsy (
33602968
)
C4b binding protein levels (
20212171
)
Mean platelet volume (
27863252
32888494
)
Platelet distribution width (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Venous thromboembolism (
31420334
31676865
)
Interacting Genes
18 interacting genes:
ALX1
C1QA
C4BPA
CALU
COL4A1
COPS5
CRP
FCGR1A
FCGR2B
FCGR3A
FCGR3B
FN1
GK
GOT2
GRB2
HES1
LAMA1
TG
11 interacting genes:
APCS
BMPR2
FXYD6
GIT2
GTF2I
HSP90AA1
LBP
LRP1
PROS1
SMARCD1
TXN
Entrez ID
325
722
HPRD ID
00101
00403
Ensembl ID
ENSG00000132703
ENSG00000123838
Uniprot IDs
P02743
V9HWP0
P04003
PDB IDs
1GYK
1LGN
1SAC
2A3W
2A3X
2A3Y
2W08
3D5O
3KQR
4AVS
4AVT
4AVV
4AYU
2A55
4B0F
5HYP
5HYT
5HYU
5HZP
5I0Q
8TCB
8TGT
Enriched GO Terms of Interacting Partners
?
IgG Binding
IgG Receptor Activity
Acute Inflammatory Response
Antibody-dependent Cellular Cytotoxicity
Hypersensitivity
Acute Inflammatory Response To Antigenic Stimulus
Lymphocyte Mediated Immunity
Immune Effector Process
Leukocyte Mediated Immunity
Leukocyte Mediated Cytotoxicity
Fc-gamma Receptor Signaling Pathway
Inflammatory Response To Antigenic Stimulus
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Immunoglobulin Mediated Immune Response
B Cell Mediated Immunity
Fc Receptor Signaling Pathway
Low-affinity IgG Receptor Activity
Cell Killing
Defense Response
Response To Other Organism
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Adaptive Immune Response
Extracellular Region
Immune Response
Inflammatory Response
Retinal Blood Vessel Morphogenesis
Response To External Biotic Stimulus
Regulation Of Immune Response
Innate Immune Response
Immune System Process
Positive Regulation Of Immune System Process
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Regulation Of Lymphocyte Mediated Immunity
Retina Vasculature Morphogenesis In Camera-type Eye
Immune Response-regulating Signaling Pathway
Cell Surface Receptor Signaling Pathway
Defense Response To Symbiont
Defense Response To Other Organism
Basement Membrane
Regulation Of Mononuclear Cell Proliferation
Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Renal Tubule Morphogenesis
Blood Vessel Morphogenesis
Regulation Of Leukocyte Proliferation
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Leukocyte Activation
Extracellular Matrix Structural Constituent
Chaperone-mediated Protein Complex Assembly
Regulation Of Multicellular Organismal Process
Acute-phase Response
Negative Regulation Of Wound Healing
Negative Regulation By Host Of Viral Glycoprotein Metabolic Process
Negative Regulation Of Multicellular Organismal Process
Acute Inflammatory Response
Regulation Of SMAD Protein Signal Transduction
Artery Morphogenesis
Clathrin-coated Pit
Protein Tyrosine Kinase Binding
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
CTP Binding
DATP Binding
Neurofibrillary Tangle Assembly
UTP Binding
Sulfonylurea Receptor Binding
Positive Regulation Of Respiratory Burst Involved In Inflammatory Response
Lipopolysaccharide Transport
Positive Regulation Of Reverse Cholesterol Transport
Positive Regulation Of Transcytosis
Alpha-2 Macroglobulin Receptor Activity
Regulation Of Transcytosis
Apolipoprotein Receptor Activity
Cellular Detoxification Of Hydrogen Peroxide
Blood Vessel Morphogenesis
Activin Receptor Activity, Type II
Rho GDP-dissociation Inhibitor Binding
Lipoprotein Particle Receptor Binding
Detoxification Of Hydrogen Peroxide
Negative Regulation Of Developmental Process
Unfolded Protein Binding
Regulation Of Lung Blood Pressure
Positive Regulation Of Multicellular Organismal Process
Pulmonary Valve Development
Tricuspid Valve Morphogenesis
Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Regulation Of Nucleocytoplasmic Transport
Astrocyte Activation Involved In Immune Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Protein-disulfide Reductase [NAD(P)H] Activity
Blood Microparticle
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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