NUDT3 and MAF1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NUDT3	MAF1
Description		nudix hydrolase 3	MAF1 negative regulator of RNA polymerase III
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Dendrite Perinuclear Region Of Cytoplasm Inhibitory Synapse
	Molecular Function	Magnesium Ion Binding Endopolyphosphatase Activity Protein Binding Zinc Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity Manganese Ion Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	RNA Polymerase III Core Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding GABA Receptor Binding
	Biological Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process RNA Decapping Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Transcription By RNA Polymerase III
Pathways		Synthesis of pyrophosphates in the cytosol	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		A body shape index ( 34021172) Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630 29381148) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Fasting insulin ( 34059833) Height ( 25429064 31562340 19893584) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Myeloproliferative neoplasms ( 33057200) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31959851 32296059) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1	9 interacting genes: CCND3 CDKN2A CSNK2A1 CSNK2A2 DDIAS LAMTOR5 MTOR NUDT3 SUMO2
Entrez ID		11165	84232
HPRD ID		14849	14345
Ensembl ID		ENSG00000272325	ENSG00000179632
Uniprot IDs		O95989	Q9H063
PDB IDs		2FVV 2Q9P 6PCK 6PCL 6WO7 6WO8 6WO9 6WOA 6WOB 6WOC 6WOD 6WOE 6WOF 6WOG 6WOH 6WOI 7TN4 8G9C 8G9D 8T98 8T99 8TF9 8TFA	3NR5
Enriched GO Terms of Interacting Partners?			Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Proteasomal Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Catabolic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Catabolic Process PML Body Negative Regulation Of Apoptotic Process Apoptotic Process SUMO Transferase Activity Programmed Cell Death Cell Death Negative Regulation Of Programmed Cell Death RNA Decapping Regulation Of Protein Localization To Nucleus PcG Protein Complex Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Protein Sumoylation Regulation Of Cell Cycle Process Autophagy Protein Destabilization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Ligase Inhibitor Activity Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Protein Serine Kinase Activity Regulation Of Chromosome Separation Regulation Of Protein Stability
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