NUDT3 and NUDT5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		NUDT3	NUDT5
Description		nudix hydrolase 3	nudix hydrolase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse	Nucleus Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Endopolyphosphatase Activity Protein Binding Zinc Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity Manganese Ion Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Magnesium Ion Binding RNA Binding Protein Binding Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity ADP-sugar Diphosphatase Activity SnoRNA Binding Identical Protein Binding Protein Homodimerization Activity 8-oxo-dGDP Phosphatase Activity Metal Ion Binding ADP-ribose Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process RNA Decapping Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process	Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Ribonucleoside Diphosphate Catabolic Process D-ribose Catabolic Process Ribose Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process ATP Generation From Poly-ADP-D-ribose
Pathways		Synthesis of pyrophosphates in the cytosol	Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630 29381148) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Fasting insulin ( 34059833) Height ( 25429064 31562340 19893584) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Myeloproliferative neoplasms ( 33057200) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1	5 interacting genes: COX5B GORASP2 MAPK6 MCM3AP NUDT3
Entrez ID		11165	11164
HPRD ID		14849	14851
Ensembl ID		ENSG00000272325	ENSG00000165609
Uniprot IDs		O95989	Q9UKK9
PDB IDs		2FVV 2Q9P 6PCK 6PCL 6WO7 6WO8 6WO9 6WOA 6WOB 6WOC 6WOD 6WOE 6WOF 6WOG 6WOH 6WOI 7TN4 8G9C 8G9D 8T98 8T99 8TF9 8TFA	2DSB 2DSC 2DSD 3AC9 3ACA 3BM4 3L85 5NQR 5NWH 5QJ4 5QJ5 5QJ6 5QJ7 5QJ8 5QJ9 5QJA 5QJB 5QJC 5QJD 5QJE 5QJF 5QJG 5QJH 5QJI 5QJJ 5QJK 5QJL 5QJM 5QJN 5QJO 5QJP 5QJQ 5QJR 5QJS 5QJT 5QJU 5QJV 5QJW 5QJX 5QJY 5QJZ 5QK0 5QK1 5QK2 5QK3 5QK4 5QK5 5QK6 5QK7 5QK8 5QK9 5QKA 5QKB 5QTL 5QTM 5QTN 5QTO 5QTP 5QTQ 5QTR 5QTS 6GRU 8PTT 8RDZ 8RIY
Enriched GO Terms of Interacting Partners?			Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Pro-T Cell Differentiation Parathyroid Hormone Secretion Septin Cytoskeleton 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Nephric Duct Formation Regulation Of Thyroid Hormone Generation Positive Regulation Of Ureteric Bud Formation Ureter Maturation Positive Regulation Of Thyroid Hormone Generation Mast Cell Differentiation Bis(5'-adenosyl)-pentaphosphatase Activity Diadenosine Polyphosphate Catabolic Process Ureteric Bud Formation Interleukin-2 Receptor Binding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Cell Proliferation Involved In Kidney Development Immune System Development Transcription Export Complex 2 Parathyroid Gland Development Mesonephric Tubule Formation Ureter Morphogenesis Otic Vesicle Development Nephric Duct Morphogenesis Norepinephrine Biosynthetic Process Histone H3 Acetyltransferase Activity T-helper 2 Cell Differentiation Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Epithelial Tube Formation Cellular Response To Interferon-alpha 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Cytochrome-c Oxidase Activity Positive Regulation Of Transcription Regulatory Region DNA Binding
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