NUDT3 and RAB17

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NUDT3	RAB17
Description		nudix hydrolase 3	RAB17, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse Glutamatergic Synapse	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Melanosome Cell Projection Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding Endopolyphosphatase Activity Protein Binding Zinc Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Pyrophosphatase Activity Hydrolase Activity Manganese Ion Binding Bis(5'-adenosyl)-hexaphosphatase Activity Bis(5'-adenosyl)-pentaphosphatase Activity Metal Ion Binding Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Diphosphoinositol Polyphosphate Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process RNA Decapping Diadenosine Pentaphosphate Catabolic Process Diadenosine Hexaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process	Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Intracellular Protein Transport Protein Transport Establishment Of Melanosome Localization Melanosome Transport Endocytic Recycling Transcytosis Filopodium Assembly Regulation Of Dendrite Development Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Cilium Assembly Anterograde Dendritic Transport Plasma Membrane Bounded Cell Projection Assembly
Pathways		Synthesis of pyrophosphates in the cytosol	RAB geranylgeranylation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Atrial fibrillation ( 29892015) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630 29381148) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 30604766) Fasting insulin ( 34059833) Height ( 25429064 31562340 19893584) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Myeloproliferative neoplasms ( 33057200) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Obesity-related traits ( 23251661)
Interacting Genes		36 interacting genes: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1	11 interacting genes: ACVR1 BOLA3 CSTPP1 FAM9B MAGEA1 NUDT3 RAB7A RABAC1 S100A8 SMURF2 SNCA
Entrez ID		11165	64284
HPRD ID		14849	11468
Ensembl ID		ENSG00000272325	ENSG00000124839
Uniprot IDs		O95989	Q9H0T7
PDB IDs		2FVV 2Q9P 6PCK 6PCL 6WO7 6WO8 6WO9 6WOA 6WOB 6WOC 6WOD 6WOE 6WOF 6WOG 6WOH 6WOI 7TN4 8G9C 8G9D 8T98 8T99 8TF9 8TFA
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Signal Transduction Endocardial Cushion Cell Fate Commitment Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Cell Communication SMAD Binding Negative Regulation Of Signaling S100A8 Complex Positive Regulation Of Secretion Calprotectin Complex Neutrophil Aggregation Response To Desipramine Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Transporter Regulator Activity Negative Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lipophagy Synaptic Vesicle Recycling Via Endosome 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Response To Lipoic Acid Establishment Of Vesicle Localization BMP Receptor Complex Peptidyl-cysteine S-nitrosylation Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Exosomal Secretion
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