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NUDT3 and HES1
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
NUDT3
HES1
Description
nudix hydrolase 3
hes family bHLH transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Synapse
Glutamatergic Synapse
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Protein-containing Complex
Molecular Function
Magnesium Ion Binding
Endopolyphosphatase Activity
Protein Binding
Zinc Ion Binding
Diphosphoinositol-polyphosphate Diphosphatase Activity
Pyrophosphatase Activity
Hydrolase Activity
Manganese Ion Binding
Bis(5'-adenosyl)-hexaphosphatase Activity
Bis(5'-adenosyl)-pentaphosphatase Activity
Metal Ion Binding
Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity
Inositol Diphosphate Pentakisphosphate Diphosphatase Activity
Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity
Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
JUN Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Protein-folding Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Cell-cell Signaling
Diadenosine Polyphosphate Catabolic Process
Diphosphoinositol Polyphosphate Metabolic Process
Diphosphoinositol Polyphosphate Catabolic Process
RNA Decapping
Diadenosine Pentaphosphate Catabolic Process
Diadenosine Hexaphosphate Catabolic Process
Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Liver Development
Inhibition Of Neuroepithelial Cell Differentiation
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Pancreatic A Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Pattern Specification Process
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Virus
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Cajal-Retzius Cell Differentiation
Neural Tube Development
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Neuron Differentiation
Lung Development
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Hair Cell Differentiation
Amacrine Cell Differentiation
Aorta Morphogenesis
Ascending Aorta Morphogenesis
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein-containing Complex Assembly
Response To Alkaloid
Positive Regulation Of DNA Binding
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Glial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Regulation Of Timing Of Cell Differentiation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Neuroendocrine Cell Differentiation
Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fatty Acid
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Negative Regulation Of Calcium Ion Import
Response To Thyroid Hormone
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Amacrine Cell Differentiation
Response To Aroclor 1254
Negative Regulation Of Cell Fate Determination
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways
Synthesis of pyrophosphates in the cytosol
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Atrial fibrillation (
29892015
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Body mass index (
20935630
29381148
)
Diastolic blood pressure (
30224653
)
Estimated glomerular filtration rate (
30604766
)
Fasting insulin (
34059833
)
Height (
25429064
31562340
19893584
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
34021172
)
Myeloproliferative neoplasms (
33057200
)
Refractive error (
32231278
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
36 interacting genes:
ALAS1
APEX1
ARL6IP1
ASB13
CCL11
CHCHD3
DBN1
DDR1
DNAJA1
EEF1G
FXYD3
HES1
ITFG1
MAF1
MCM5
MEX3B
NR2C1
NUDT5
OAT
PDCD5
PEX5
PRKD3
RAB17
REEP5
RNF126
RPL17
RPL8
RPLP1
SOX30
TNNT3
TUBA1A
TUBGCP4
UBR1
VPS51
WDR74
XPNPEP1
36 interacting genes:
ALK
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
RUNX2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
11165
3280
HPRD ID
14849
00770
Ensembl ID
ENSG00000272325
ENSG00000114315
Uniprot IDs
O95989
Q14469
PDB IDs
2FVV
2Q9P
6PCK
6PCL
6WO7
6WO8
6WO9
6WOA
6WOB
6WOC
6WOD
6WOE
6WOF
6WOG
6WOH
6WOI
7TN4
8G9C
8G9D
8T98
8T99
8TF9
8TFA
2MH3
7C4O
Enriched GO Terms of Interacting Partners
?
Fanconi Anaemia Nuclear Complex
Regulation Of Cell Differentiation
Transcription Regulator Inhibitor Activity
Nucleus
Protein Dimerization Activity
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Interstrand Cross-link Repair
Animal Organ Development
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cellular Developmental Process
Developmental Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Nucleoplasm
Cell Differentiation
Regulation Of Developmental Process
Circadian Rhythm
Regulation Of Primary Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Development
Transcription Regulator Complex
Neuron Differentiation
Rhythmic Process
Animal Organ Morphogenesis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Apoptotic Process
Response To Stress
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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