NUDT3 and XPNPEP1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		NUDT3	XPNPEP1
Gene Name		nudix (nucleoside diphosphate linked moiety X)-type motif 3	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity	Aminopeptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity
	Biological Process	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process	Proteolysis Bradykinin Catabolic Process
Pathways		Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS		Body mass index ( 20935630) Height ( 19893584)	Biliary atresia ( 20460270)
Protein-Protein Interactions		36 interactors: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1	8 interactors: DISC1 GSK3B MAPK9 NUDT3 POLA2 RINT1 UBC UBE2D3
Entrez ID		11165	7511
HPRD ID		14849	03899
Ensembl ID			ENSG00000108039
Uniprot IDs		O95989	G8JLB2 Q9NQW7
PDB IDs		2FVV 2Q9P	3CTZ
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Cellular Metabolic Process Protein Targeting Intracellular Transport Protein Localization To Organelle Cellular Localization Cellular Protein Localization Translational Elongation Establishment Of Protein Localization To Organelle Catabolic Process Protein Localization To Membrane Protein Localization Intracellular Protein Transport Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Process Establishment Of Localization In Cell Protein Targeting To ER Cytoplasmic Transport Aromatic Compound Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum DNA Strand Elongation Involved In DNA Replication Establishment Of Protein Localization Branching Involved In Mammary Gland Duct Morphogenesis DNA Strand Elongation Translational Termination Membrane Organization Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Metabolic Process MRNA Catabolic Process Transcription Factor TFIIIB Complex Assembly Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Mammary Gland Duct Morphogenesis RNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Interleukin-4 Cellular Protein Complex Disassembly Viral Life Cycle	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Innate Immune Response Cellular Localization Response To Growth Factor Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Protein Ubiquitination Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Fc-epsilon Receptor Signaling Pathway Intracellular Transport Regulation Of Innate Immune Response Fc Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Type I Interferon Production Regulation Of Wnt Signaling Pathway Regulation Of Immune Response Positive Regulation Of Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress Protein Localization Apoptotic Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Apoptotic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Establishment Of Localization In Cell Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Catabolic Process Cell Death Death MyD88-dependent Toll-like Receptor Signaling Pathway Response To Abiotic Stimulus
Tagcloud ?			aminopeptidase app app1 apps associate biologically causal cleave cytosolic deficiency deficient excretion imino isoforms knocking lethality link mammals microcephaly modest oligopeptide penultimate peptides peptiduria proline ps residue retardation
Tagcloud (Difference) ?			aminopeptidase app app1 apps associate biologically causal cleave cytosolic deficiency deficient excretion imino isoforms knocking lethality link mammals microcephaly modest oligopeptide penultimate peptides peptiduria proline ps residue retardation
Tagcloud (Intersection) ?