HOXB1 and MEIS1

Number of citations of the paper that reports this interaction (PMID 10373562)
61

Data Source:
HPRD (in vitro)

		HOXB1	MEIS1
Gene Name		homeobox B1	Meis homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	DNA Binding Protein Domain Specific Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Pattern Specification Process Anterior/posterior Pattern Specification Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis	Angiogenesis Lens Morphogenesis In Camera-type Eye Transcription From RNA Polymerase II Promoter Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS		Primary tooth development (number of teeth) ( 20195514)	PR interval ( 20062060 23139255) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		8 interactors: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 SERPINA3	27 interactors: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3211	4211
HPRD ID		00855	03442
Ensembl ID			ENSG00000143995
Uniprot IDs		P14653	F5GYS8 F8W8U3 O00470
PDB IDs		1B72
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process N-terminal Protein Amino Acid Acetylation Negative Regulation Of Neuron Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Anterior/posterior Pattern Specification Stem Cell Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neurogenesis Regulation Of Metabolic Process Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cell Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Cell Development Regulation Of DNA-templated Transcription In Response To Stress Organ Morphogenesis Positive Regulation Of Metabolic Process Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Immune System Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Type I Interferon Production Negative Regulation Of RNA Biosynthetic Process Embryo Development Histone H2B Acetylation Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Negative Regulation Of Apoptotic Cell Clearance Pancreatic A Cell Development Nervous System Development Transcription, DNA-templated Pattern Specification Process RNA Biosynthetic Process	Anterior/posterior Pattern Specification Pattern Specification Process Embryonic Morphogenesis Transcription, DNA-templated Skeletal System Development Embryonic Skeletal System Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Multicellular Organismal Development System Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Embryonic Skeletal System Morphogenesis RNA Metabolic Process Limb Development Embryo Development Gene Expression Organ Development Developmental Process Organ Morphogenesis Embryonic Limb Morphogenesis Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Macromolecule Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Proximal/distal Pattern Formation Positive Regulation Of Transcription, DNA-templated Skeletal System Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Organ Morphogenesis Regulation Of Metabolic Process Embryonic Organ Development Cellular Nitrogen Compound Metabolic Process Chordate Embryonic Development Nitrogen Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Embryonic Forelimb Morphogenesis
Tagcloud ?		blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		blastocyst chx cycloheximide embryo embryos establishment ezh2 fertilisation gata6 giant h3k27me2 hand1 homologue lethality microinjecting nanog novo oct4 outgrowth pluripotency preimplantation pronuclear restrict retardation sox2 tri trophoblast zeste zygotes	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?