HOXB1 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 123121)
0

Data Source:
HPRD (in vivo)

		HOXB1	SERPINA3
Description		homeobox B1	serpin family A member 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Rhombomere Development Rhombomere 4 Development Rhombomere 5 Development Facial Nerve Structural Organization Facial Nucleus Development Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Morphogenesis	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 26426971) Colorectal or endometrial cancer ( 26621817) Hemoglobin levels ( 32327693) Keratoconus ( 33649486) Primary tooth development (number of teeth) ( 20195514) Waist circumference ( 28552196)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		10 interacting genes: CREBBP EP300 HMGB1 MEIS1 PAX6 PBX1 PKNOX2 RCHY1 SERPINA3 ZNF835	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		3211	12
HPRD ID		00855	00120
Ensembl ID		ENSG00000120094	ENSG00000196136
Uniprot IDs		P14653	P01011
PDB IDs		1B72	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Eye Development DNA Binding Transcription Coregulator Binding Sensory Organ Development DNA-binding Transcription Factor Binding Regulation Of Primary Metabolic Process Damaged DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex P53 Binding Negative Regulation Of Neuron Differentiation Chromatin DNA Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Acetyltransferase Activity Pattern Specification Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Cell Development Regulation Of RNA Metabolic Process Megakaryocyte Development Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Sequence-specific DNA Binding Anterior/posterior Pattern Specification Chromatin Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hemopoiesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone Acetyltransferase Activity Animal Organ Morphogenesis Regulation Of Neuron Differentiation Protein Acetylation Chromatin Activation Of Innate Immune Response Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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