PYCR1 and CDK2AP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PYCR1	CDK2AP2
Gene Name		pyrroline-5-carboxylate reductase 1	cyclin-dependent kinase 2 associated protein 2
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Identical Protein Binding
	Biological Process	Proline Biosynthetic Process Cellular Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Regulation Of Mitochondrial Membrane Potential Oxidation-reduction Process L-proline Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs		NADH L-Proline
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BNIPL CDK2AP2 HNRNPD NUDT21	17 interactors: A2M APP CDK2AP1 DBN1 EED EEF1G HSF4 IKZF1 MBTPS1 MRFAP1L1 PYCR1 RCC1 RPLP1 TRA2A WARS YIF1A ZBTB48
Entrez ID		5831	10263
HPRD ID		01528	13242
Ensembl ID		ENSG00000183010	ENSG00000167797
Uniprot IDs		B4DMU0 E2QRB3 P32322 Q8TBX0	O75956 Q6IAV4
PDB IDs		2GER 2GR9 2GRA 2IZZ	2M1L
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Growth Rate RNA Splicing Circadian Regulation Of Translation MRNA Processing MRNA Metabolic Process RNA Processing MRNA Polyadenylation RNA Polyadenylation Termination Of RNA Polymerase II Transcription Regulation Of MRNA Stability Regulation Of RNA Stability	Gene Expression Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclease Activity Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Platelet Degranulation Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Complement Activation, Lectin Pathway Cellular Aromatic Compound Metabolic Process Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Regulation Of Multicellular Organism Growth Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Modification Process Cholesterol Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition L-proline Biosynthetic Process Sterol Metabolic Process Response To Unfolded Protein Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Hydrolase Activity Protein Metabolic Process Axon Choice Point Recognition Positive Regulation Of NK T Cell Differentiation Regulation Of Protein Phosphorylation MRNA Metabolic Process Histone H3-K9 Demethylation Response To Endoplasmic Reticulum Stress Positive Regulation Of Ran GTPase Activity Positive Regulation Of Granulocyte Differentiation
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