PYCR1 and SIRT3

Number of citations of the paper that reports this interaction (PubMedID 31108370)
35

Data Source:
BioGRID (pull down)

		PYCR1	SIRT3
Description		pyrroline-5-carboxylate reductase 1	sirtuin 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent Enzyme Binding Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Sequence-specific DNA Binding Metal Ion Binding NAD+ Binding NAD-dependent Protein Lysine Delactylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Protein Deacetylation Aerobic Respiration Positive Regulation Of Insulin Secretion Cellular Response To Stress Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Glutamate and glutamine metabolism	Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Mitochondrial unfolded protein response (UPRmt) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		NADH Proline	Adenosine-5-Diphosphoribose
Diseases		Geroderma osteodysplasticum
GWAS			Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2	11 interacting genes: ALDH2 DNM1L ECHS1 GLDC H3C1 MCL1 MDM2 PDP1 PEX5 PYCR1 XRCC6
Entrez ID		5831	23410
HPRD ID		01528	06836
Ensembl ID		ENSG00000183010	ENSG00000142082
Uniprot IDs		E2QRB3 J3QL32 P32322 Q8TBX0	E9PK80 E9PM75 E9PN58 Q9NTG7
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3 8DKG 8TCU 8TCV 8TCW 8TCX 8TCY 8TCZ 8TD0 8TD1 8TD2 8TD3 8TD4 8TD5 8TD6 8TD7 8TD8 8TD9 8TDB 8TDC 8TDD 8VRE	3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO 8ANC 8BBK 8CCW 8CCZ 8HLW 8HLY 8HN9 8V15 8V2N 8V5U 9CBT
Enriched GO Terms of Interacting Partners?		MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of MRNA Catabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine MRNA Binding Positive Regulation Of Pro-B Cell Differentiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of MRNA Metabolic Process Circadian Regulation Of Translation Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Histone Deacetylase Binding Nucleus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Lymphoid Progenitor Cell Differentiation Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process MRNA Alternative Polyadenylation Positive Regulation Of Translation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Strand Annealing Activity Nuclear Pore Localization Histone Deacetylase Activity, NAD-dependent Regulation Of Growth Rate Response To Rapamycin Regulation Of MRNA Stability Cell Dedifferentiation Intracellular Membraneless Organelle MRNA Cleavage Factor Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Ceramide Biosynthetic Process NAD-dependent Protein Lysine Deacetylase Activity Regulation Of RNA Stability Regulation Of Pro-B Cell Differentiation Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Nuclear Pore Complex Assembly Paraspeckles CRD-mediated MRNA Stabilization	Mitochondrion Mitochondrial Matrix Cellular Response To Chemical Stress Protein-containing Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Lyase Activity Cellular Response To Gamma Radiation Electron Transfer Activity Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process 3-hydroxypropionyl-CoA Dehydratase Activity Fatty Acid Beta-oxidation Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Response To Gamma Radiation Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Formaldehyde Cellular Response To Oxidative Stress Cellular Response To Vitamin B1 Endoplasmic Reticulum Organization Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Carboxylic Acid Metabolic Process Apoptotic Mitochondrial Changes Organic Acid Metabolic Process Cellular Response To Ionizing Radiation Small Molecule Metabolic Process Fatty Acid Catabolic Process Crotonyl-CoA Hydratase Activity Fatty Acid Oxidation Response To Lipoic Acid Protein Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Lipid Oxidation Response To Oxidative Stress DNA End Binding Cellular Response To Stress Ku70:Ku80 Complex Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Glycine Catabolic Process
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