PYCR1 and BNIPL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PYCR1	BNIPL
Description		pyrroline-5-carboxylate reductase 1	BCL2 interacting protein like
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Mitochondrial Membrane Potential L-proline Biosynthetic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Growth Rate
Pathways		Glutamate and glutamine metabolism
Drugs		NADH Proline
Diseases		Geroderma osteodysplasticum
GWAS			Body mass index ( 26426971) Chronic kidney disease ( 20383146) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: BNIPL CDK2AP2 FXR1 HNRNPD NUDT21 SIRT3 TNPO2	13 interacting genes: ARHGAP1 BCL2 BCL2L1 BNIP2 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 RHOU SNAPIN
Entrez ID		5831	149428
HPRD ID		01528	16557
Ensembl ID		ENSG00000183010	ENSG00000163141
Uniprot IDs		E2QRB3 J3QL32 P32322 Q8TBX0	Q7Z465
PDB IDs		2GER 2GR9 2GRA 2IZZ 5UAT 5UAU 5UAV 5UAW 5UAX 6XOZ 6XP0 6XP1 6XP2 6XP3 8DKG 8TCU 8TCV 8TCW 8TCX 8TCY 8TCZ 8TD0 8TD1 8TD2 8TD3 8TD4 8TD5 8TD6 8TD7 8TD8 8TD9 8TDB 8TDC 8TDD 8VRE
Enriched GO Terms of Interacting Partners?		MRNA 3'-UTR AU-rich Region Binding Negative Regulation Of MRNA Catabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine MRNA Binding Positive Regulation Of Pro-B Cell Differentiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of RNA Catabolic Process Regulation Of Circadian Rhythm Negative Regulation Of MRNA Metabolic Process Circadian Regulation Of Translation Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Histone Deacetylase Binding Nucleus Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Lymphoid Progenitor Cell Differentiation Peptidyl-lysine Deacetylation Positive Regulation Of Oxidative Phosphorylation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process MRNA Alternative Polyadenylation Positive Regulation Of Translation Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex RNA Strand Annealing Activity Nuclear Pore Localization Histone Deacetylase Activity, NAD-dependent Regulation Of Growth Rate Response To Rapamycin Regulation Of MRNA Stability Cell Dedifferentiation Intracellular Membraneless Organelle MRNA Cleavage Factor Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Ceramide Biosynthetic Process NAD-dependent Protein Lysine Deacetylase Activity Regulation Of RNA Stability Regulation Of Pro-B Cell Differentiation Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Nuclear Pore Complex Assembly Paraspeckles CRD-mediated MRNA Stabilization	Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Protein Homotrimerization Regulation Of Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Trimerization Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Anoikis Regulation Of B Cell Apoptotic Process Cytosol Negative Regulation Of Myeloid Cell Apoptotic Process Identical Protein Binding Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Isomerase Activity Regulation Of Anoikis Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Leukocyte Proliferation Sensory Organ Development Regulation Of Myeloid Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Lymphocyte Apoptotic Process Cellular Response To Alkaloid Pigment Granule Organization Channel Activity Regulation Of Cellular Localization Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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