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PYCR1

Gene Name pyrroline-5-carboxylate reductase 1
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Gene Ontology Annotations Cellular Component
  • Mitochondrion
  • Mitochondrial Matrix
Molecular Function
  • Pyrroline-5-carboxylate Reductase Activity
  • Protein Binding
  • Identical Protein Binding
Biological Process
  • Proline Biosynthetic Process
  • Cellular Amino Acid Biosynthetic Process
  • Cellular Response To Oxidative Stress
  • Cellular Nitrogen Compound Metabolic Process
  • Small Molecule Metabolic Process
  • Regulation Of Mitochondrial Membrane Potential
  • Oxidation-reduction Process
  • L-proline Biosynthetic Process
  • Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways
  • Amino acid synthesis and interconversion (transamination)
  • Metabolism of amino acids and derivatives
Drugs
  • NADH
  • L-Proline
Diseases
GWAS
Protein-protein Interactions 4 interactors: BNIPL CDK2AP2 HNRNPD NUDT21
Entrez ID 5831
HPRD ID 01528
Ensembl ID ENSG00000183010
Uniprot IDs B4DMU0 E2QRB3 P32322 Q8TBX0
PDB IDs 2GER 2GR9 2GRA 2IZZ
Enriched GO Terms of Interacting Partners?
  • MRNA Splicing, Via Spliceosome
  • RNA Splicing, Via Transesterification Reactions
  • Regulation Of Growth Rate
  • RNA Splicing
  • Circadian Regulation Of Translation
  • MRNA Processing
  • MRNA Metabolic Process
  • RNA Processing
  • MRNA Polyadenylation
  • RNA Polyadenylation
  • Termination Of RNA Polymerase II Transcription
  • Regulation Of MRNA Stability
  • Regulation Of RNA Stability
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