CYCS and CYC1

Number of citations of the paper that reports this interaction (PMID 6262312)
8

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		CYCS	CYC1
Gene Name		cytochrome c, somatic	cytochrome c-1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Integral Component Of Membrane Respiratory Chain
	Molecular Function	Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity	Iron Ion Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity
	Biological Process	Response To Reactive Oxygen Species Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic DNA Fragmentation Apoptotic Process Organelle Organization Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Dephosphorylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Respiratory Electron Transport Chain Response To Glucagon Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Detoxification of Reactive Oxygen Species Respiratory electron transport Cytochrome c-mediated apoptotic response Mitochondrial biogenesis Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response Programmed Cell Death Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Orphan transporters Intrinsic Pathway for Apoptosis	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport Mitochondrial protein import The citric acid (TCA) cycle and respiratory electron transport
Drugs		Minocycline Protoporphyrin Ix Containing Co Heme Heme C Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		20 interactors: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	2 interactors: CYCS UQCRFS1
Entrez ID		54205	1537
HPRD ID		00479	00480
Ensembl ID			ENSG00000179091
Uniprot IDs		G4XXL9 P99999	P08574
PDB IDs		1J3S 3NWV
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Alkaloid Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Cellular Respiration Cell Death Death Neuron Apoptotic Process Regulation Of Cell Death Mitochondrial Membrane Organization Response To Biotic Stimulus Neuron Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Anoikis Regulation Of Neuron Death Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Energy Derivation By Oxidation Of Organic Compounds Zymogen Activation Programmed Cell Death Respiratory Electron Transport Chain Positive Regulation Of Cell Death Regulation Of Anoikis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Biosynthetic Process Response To Metal Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Electron Transport Chain Sterol Metabolic Process Positive Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Response To Other Organism Positive Regulation Of Peptidase Activity Mitochondrion Organization Small Molecule Metabolic Process	Respiratory Electron Transport Chain Electron Transport Chain Cellular Respiration Energy Derivation By Oxidation Of Organic Compounds Mitochondrial Electron Transport, Cytochrome C To Oxygen Generation Of Precursor Metabolites And Energy Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic DNA Fragmentation Apoptotic Nuclear Changes Oxidation-reduction Process Mitochondrial ATP Synthesis Coupled Electron Transport Response To Antibiotic Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transmembrane Transport Oxidative Phosphorylation Execution Phase Of Apoptosis
Tagcloud ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	centers cleavage cloned ded1 intermittently mapped mgcl2 nacl nuclease oligopurine oligopyrimidine opened p1 plasmids promoters ready reside spermine strand supercoiled supercoiling superhelical topoisomer torsional tracts turns unwinding unwound
Tagcloud (Difference) ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	centers cleavage cloned ded1 intermittently mapped mgcl2 nacl nuclease oligopurine oligopyrimidine opened p1 plasmids promoters ready reside spermine strand supercoiled supercoiling superhelical topoisomer torsional tracts turns unwinding unwound
Tagcloud (Intersection) ?