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CYCS and SAFB
Number of citations of the paper that reports this interaction (PubMedID
11784858
)
84
Data Source:
HPRD
(in vivo)
CYCS
SAFB
Description
cytochrome c, somatic
scaffold attachment factor B
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Apoptosome
Nucleus
Nucleoplasm
Midbody
Molecular Function
Protein Binding
Electron Transfer Activity
Heme Binding
Metal Ion Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
RNA Binding
Protein Binding
Sequence-specific DNA Binding
Biological Process
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Apoptotic Process
Cellular Respiration
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Estrogen Receptor Signaling Pathway
Regulation Of MRNA Processing
Regulation Of Androgen Receptor Signaling Pathway
Pathways
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
Pyroptosis
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Cytoprotection by HMOX1
SUMOylation of transcription cofactors
Drugs
Minocycline
Protoporphyrin Ix Containing Co
Ferroheme C
Imidazole
Zinc protoporphyrin
Trimethyllysine
Zinc Substituted Heme C
Artenimol
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
High density lipoprotein cholesterol levels (
30498476
)
Systemic lupus erythematosus (
19838195
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
22 interacting genes:
AGTPBP1
APAF1
BCL2
BCL2L1
CASP9
COX4I2
CUL9
CYB5A
CYB5R1
CYB5R3
CYC1
FDX1
HSPA8
HSPB1
KRT40
MEOX2
NDOR1
RNF7
SAFB
SNCA
UQCRC1
VDAC2
30 interacting genes:
ABHD16A
CDC37
CEBPA
CHD1
CHD3
CLK1
CSNK2A1
CYCS
ESR1
HNRNPA1
HNRNPD
HNRNPK
IL7R
LINC00941
MIR199A1
MIR363
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7D
NCOR1
POLR2A
SAFB2
SREK1
SRPK1
SRPK2
SRSF9
SUMO2
TAF15
TJP2
Entrez ID
54205
6294
HPRD ID
00479
04205
Ensembl ID
ENSG00000172115
ENSG00000160633
Uniprot IDs
G4XXL9
P99999
B7Z2F6
B7ZLP5
Q15424
PDB IDs
1J3S
2N3Y
2N9I
2N9J
3NWV
3ZCF
3ZOO
5EXQ
5O10
5TY3
6DUJ
6ECJ
6XNK
Enriched GO Terms of Interacting Partners
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Electron Transport Chain
Mitochondrial Outer Membrane
Mitochondrion
Neuron Apoptotic Process
Generation Of Precursor Metabolites And Energy
Mitochondrial Membrane
Apoptosome
Dendritic Cell Apoptotic Process
Respiratory Electron Transport Chain
Mitochondrial Membrane Organization
Mitochondrion Organization
Quinol-cytochrome-c Reductase Activity
FAD Binding
BH3 Domain Binding
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Epithelial Cell Apoptotic Process
Leukocyte Apoptotic Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Bcl-2 Family Protein Complex
Electron Transfer Activity
Intrinsic Apoptotic Signaling Pathway
Respiratory Chain Complex III
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Apoptotic Mitochondrial Changes
Regulation Of Membrane Permeability
Pore Complex
Aerobic Electron Transport Chain
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Steroid Biosynthetic Process
Mitochondrial Inner Membrane
Response To Alkaloid
Platelet Alpha Granule Membrane
Aerobic Respiration
Negative Regulation Of Anoikis
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Autophagy
Programmed Cell Death Involved In Cell Development
Cellular Respiration
Oxidative Phosphorylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Cytosol
Positive Regulation Of Apoptotic Process
Regulation Of Anoikis
Ubiquitin Protein Ligase Binding
Sterol Metabolic Process
Protein Refolding
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of MRNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulatory NcRNA-mediated Gene Silencing
Regulation Of Metabolic Process
Regulation Of RNA Splicing
MiRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Regulation Of Gene Expression
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Regulation Of MRNA Processing
Post-transcriptional Gene Silencing
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
RISC Complex
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
RNA Splicing
MRNA Base-pairing Post-transcriptional Repressor Activity
Nucleoplasm
Negative Regulation Of Metabolic Process
Nucleic Acid Binding
RNA Binding
MRNA Metabolic Process
Chromatin
RNA Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of MRNA Metabolic Process
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Protein Domain Specific Binding
Positive Regulation Of Catabolic Process
MRNA 3'-UTR Binding
Chromatin Organization
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Processing
MRNA Processing
DNA Binding
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of MRNA Stability
Nucleus
Nucleic Acid Metabolic Process
ATP-dependent Chromatin Remodeler Activity
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Tagcloud (Intersection)
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