CYCS and HSPB1

Number of citations of the paper that reports this interaction (PMID 10980706)
144

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		CYCS	HSPB1
Gene Name		cytochrome c, somatic	heat shock 27kDa protein 1
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity	Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Ubiquitin Binding Poly(A) RNA Binding
	Biological Process	Response To Reactive Oxygen Species Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic DNA Fragmentation Apoptotic Process Organelle Organization Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Dephosphorylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Retina Homeostasis Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Movement Of Cell Or Subcellular Component Response To Unfolded Protein Response To Virus Gene Expression Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Detoxification of Reactive Oxygen Species Respiratory electron transport Cytochrome c-mediated apoptotic response Mitochondrial biogenesis Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response Programmed Cell Death Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Orphan transporters Intrinsic Pathway for Apoptosis	Regulation of mRNA stability by proteins that bind AU-rich elements Signaling by VEGF AUF1 (hnRNP D0) destabilizes mRNA VEGFA-VEGFR2 Pathway
Drugs		Minocycline Protoporphyrin Ix Containing Co Heme Heme C Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		20 interactors: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	40 interactors: ACTC1 AKT1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX EFTUD2 EIF4G1 HNRNPD HSPB8 IGSF21 INS LBP LRIF1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MED31 MFAP1 NFKBIA PLG POP7 PPA1 PPM1A PRKD1 PRPF19 RBM48 RPS6KA5 SERTAD1 SF3B3 SMARCD1 SNCA TGFB1I1 TGM1 TP53 UCHL5 WDR83
Entrez ID		54205	3315
HPRD ID		00479	09076
Ensembl ID			ENSG00000106211
Uniprot IDs		G4XXL9 P99999	P04792
PDB IDs		1J3S 3NWV	3Q9P 3Q9Q
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Alkaloid Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Cellular Respiration Cell Death Death Neuron Apoptotic Process Regulation Of Cell Death Mitochondrial Membrane Organization Response To Biotic Stimulus Neuron Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Anoikis Regulation Of Neuron Death Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Energy Derivation By Oxidation Of Organic Compounds Zymogen Activation Programmed Cell Death Respiratory Electron Transport Chain Positive Regulation Of Cell Death Regulation Of Anoikis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Biosynthetic Process Response To Metal Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Electron Transport Chain Sterol Metabolic Process Positive Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Response To Other Organism Positive Regulation Of Peptidase Activity Mitochondrion Organization Small Molecule Metabolic Process	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of Transport Positive Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Signal Transduction By Phosphorylation Cellular Response To Stress Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Response To Stress Peptidyl-serine Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Organic Substance Intracellular Signal Transduction Activation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Reactive Oxygen Species Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Transport MyD88-dependent Toll-like Receptor Signaling Pathway Gene Expression
Tagcloud ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Difference) ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	adenocarcinomas adenoma antiapoptotic bax bcl2 cytotoxic elisa exists follows fresh gland glands glandular hsp27 immunosorbent messenger neoplasm neoplasms oesophageal origin pa pleomorphic positively ribonucleic salivary stresses tolerance tumours whose
Tagcloud (Intersection) ?