CYCS and NDOR1

Number of citations of the paper that reports this interaction (PMID 10625700)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CYCS	NDOR1
Gene Name		cytochrome c, somatic	NADPH dependent diflavin oxidoreductase 1
Image
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain	Nucleus Cytoplasm Cytosol Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity	NADPH-hemoprotein Reductase Activity Iron Ion Binding Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Response To Reactive Oxygen Species Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic DNA Fragmentation Apoptotic Process Organelle Organization Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Dephosphorylation Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Cellular Respiration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway	Cell Death Iron-sulfur Cluster Assembly Cellular Response To Menadione Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Organelle biogenesis and maintenance Detoxification of Reactive Oxygen Species Respiratory electron transport Cytochrome c-mediated apoptotic response Mitochondrial biogenesis Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Release of apoptotic factors from the mitochondria Apoptotic factor-mediated response Programmed Cell Death Transcriptional activation of mitochondrial biogenesis The citric acid (TCA) cycle and respiratory electron transport Orphan transporters Intrinsic Pathway for Apoptosis	Cytosolic iron-sulfur cluster assembly
Drugs		Minocycline Protoporphyrin Ix Containing Co Heme Heme C Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		20 interactors: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2	8 interactors: CCDC33 CIAPIN1 CYCS DLG4 EFHC2 MTUS2 TCF4 TCHP
Entrez ID		54205	27158
HPRD ID		00479	10444
Ensembl ID			ENSG00000188566
Uniprot IDs		G4XXL9 P99999	D3YTG6 Q9UHB4
PDB IDs		1J3S 3NWV	4H2D
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Alkaloid Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Cellular Respiration Cell Death Death Neuron Apoptotic Process Regulation Of Cell Death Mitochondrial Membrane Organization Response To Biotic Stimulus Neuron Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway L-ascorbic Acid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Anoikis Regulation Of Neuron Death Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Energy Derivation By Oxidation Of Organic Compounds Zymogen Activation Programmed Cell Death Respiratory Electron Transport Chain Positive Regulation Of Cell Death Regulation Of Anoikis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Biosynthetic Process Response To Metal Ion Positive Regulation Of Cysteine-type Endopeptidase Activity Electron Transport Chain Sterol Metabolic Process Positive Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Response To Other Organism Positive Regulation Of Peptidase Activity Mitochondrion Organization Small Molecule Metabolic Process	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Apoptotic Process Programmed Cell Death Vesicle Localization Maintenance Of DNA Repeat Elements Mitochondrial Electron Transport, Cytochrome C To Oxygen Cell Death Death Negative Regulation Of Growth Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Maintenance Of Apical/basal Cell Polarity Embryonic Genitalia Morphogenesis Receptor Localization To Synapse Myoblast Fate Commitment Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Receptor Internalization Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Secretory Granule Localization Locomotory Exploration Behavior Regulation Of Apoptotic Process Hindgut Morphogenesis Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Insulin Metabolic Process Maintenance Of Cell Polarity Regulation Of Cell Death Hindgut Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Vocalization Behavior Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Generation Of Precursor Metabolites And Energy Organelle Localization Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Dendritic Spine Development Protein Localization To Synapse Positive Regulation Of Gluconeogenesis Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Apoptotic DNA Fragmentation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Dendritic Spine Organization Cellular Component Assembly
Tagcloud ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	abcc3 agilent ankrd46 begins bonferroni c1orf9 c6orf62 cd47 chernobyl david fallout fgfr1op2 frozen hey2 hnrnph1 hybridised iodine kruskal multistep panther purposes qrt representation scel serpina1 ucp3 ukrainian unirradiated wallis
Tagcloud (Difference) ?		alternate apical apoptosome apoptotic atg5 atg7 autophagic autophagosome autophagy bak1 casp8 casp9 caspase caspases chemoresistance coincides cytochrome defective devoid existence facilitating fadd highlighting impacted normally platform problem revealing tackling	abcc3 agilent ankrd46 begins bonferroni c1orf9 c6orf62 cd47 chernobyl david fallout fgfr1op2 frozen hey2 hnrnph1 hybridised iodine kruskal multistep panther purposes qrt representation scel serpina1 ucp3 ukrainian unirradiated wallis
Tagcloud (Intersection) ?