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CYCS and CYB5A
Number of citations of the paper that reports this interaction (PubMedID
199233
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
CYCS
CYB5A
Description
cytochrome c, somatic
cytochrome b5 type A
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Apoptosome
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Electron Transfer Activity
Heme Binding
Metal Ion Binding
Protein Binding
Enzyme Binding
Heme Binding
Metal Ion Binding
Biological Process
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Apoptotic Process
Cellular Respiration
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Pathways
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
Pyroptosis
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Cytoprotection by HMOX1
Vitamin C (ascorbate) metabolism
Drugs
Minocycline
Protoporphyrin Ix Containing Co
Ferroheme C
Imidazole
Zinc protoporphyrin
Trimethyllysine
Zinc Substituted Heme C
Artenimol
Dimethyl Propionate Ester Heme
Chromium
Chromic citrate
Chromic nitrate
Chromium gluconate
Chromium nicotinate
Chromous sulfate
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Methemoglobinemia
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
High density lipoprotein cholesterol levels (
30498476
)
Systemic lupus erythematosus (
19838195
)
Blood protein levels (
30072576
)
Interacting Genes
22 interacting genes:
AGTPBP1
APAF1
BCL2
BCL2L1
CASP9
COX4I2
CUL9
CYB5A
CYB5R1
CYB5R3
CYC1
FDX1
HSPA8
HSPB1
KRT40
MEOX2
NDOR1
RNF7
SAFB
SNCA
UQCRC1
VDAC2
14 interacting genes:
CYB5R3
CYCS
CYP17A1
CYP1A1
CYP1A2
CYP2A6
CYP2D6
CYP2E1
CYP2W1
CYP3A4
CYP4A11
POR
SCD
UGT1A4
Entrez ID
54205
1528
HPRD ID
00479
08941
Ensembl ID
ENSG00000172115
ENSG00000166347
Uniprot IDs
G4XXL9
P99999
A0A384ME44
P00167
PDB IDs
1J3S
2N3Y
2N9I
2N9J
3NWV
3ZCF
3ZOO
5EXQ
5O10
5TY3
6DUJ
6ECJ
6XNK
2I96
Enriched GO Terms of Interacting Partners
?
Electron Transport Chain
Mitochondrial Outer Membrane
Mitochondrion
Neuron Apoptotic Process
Generation Of Precursor Metabolites And Energy
Mitochondrial Membrane
Apoptosome
Dendritic Cell Apoptotic Process
Respiratory Electron Transport Chain
Mitochondrial Membrane Organization
Mitochondrion Organization
Quinol-cytochrome-c Reductase Activity
FAD Binding
BH3 Domain Binding
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Epithelial Cell Apoptotic Process
Leukocyte Apoptotic Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Bcl-2 Family Protein Complex
Electron Transfer Activity
Intrinsic Apoptotic Signaling Pathway
Respiratory Chain Complex III
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Apoptotic Mitochondrial Changes
Regulation Of Membrane Permeability
Pore Complex
Aerobic Electron Transport Chain
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Steroid Biosynthetic Process
Mitochondrial Inner Membrane
Response To Alkaloid
Platelet Alpha Granule Membrane
Aerobic Respiration
Negative Regulation Of Anoikis
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Autophagy
Programmed Cell Death Involved In Cell Development
Cellular Respiration
Oxidative Phosphorylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Cytosol
Positive Regulation Of Apoptotic Process
Regulation Of Anoikis
Ubiquitin Protein Ligase Binding
Sterol Metabolic Process
Protein Refolding
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
Iron Ion Binding
Heme Binding
Monooxygenase Activity
Xenobiotic Metabolic Process
Oxidoreductase Activity
Endoplasmic Reticulum Membrane
Lipid Metabolic Process
Steroid Metabolic Process
Olefinic Compound Metabolic Process
Intracellular Membrane-bounded Organelle
Small Molecule Metabolic Process
Monocarboxylic Acid Metabolic Process
Endoplasmic Reticulum
Fatty Acid Metabolic Process
Epoxygenase P450 Pathway
Unsaturated Fatty Acid Metabolic Process
Arachidonate Metabolic Process
Long-chain Fatty Acid Metabolic Process
Secondary Metabolic Process
Monoterpenoid Metabolic Process
Small Molecule Biosynthetic Process
Xenobiotic Catabolic Process
Carboxylic Acid Metabolic Process
Organic Acid Metabolic Process
Terpenoid Metabolic Process
Long-chain Fatty Acid Biosynthetic Process
Icosanoid Metabolic Process
Demethylation
Isoprenoid Metabolic Process
Fatty Acid Biosynthetic Process
Coumarin Metabolic Process
Carboxylic Acid Biosynthetic Process
Steroid Hydroxylase Activity
Toxin Metabolic Process
Alcohol Metabolic Process
Lipid Biosynthetic Process
Retinoid Metabolic Process
Diterpenoid Metabolic Process
Hormone Metabolic Process
Oxygen Binding
Lipid Hydroxylation
Enzyme Binding
Estrogen Metabolic Process
Estrogen 16-alpha-hydroxylase Activity
Estrogen 2-hydroxylase Activity
Oxidative Demethylation
Aflatoxin Metabolic Process
Alkaloid Metabolic Process
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Tagcloud (Intersection)
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