POLA2 and STK40

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	STK40
Gene Name		polymerase (DNA directed), alpha 2, accessory subunit	serine/threonine kinase 40
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm	Nucleoplasm Cytoplasm
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Respiratory System Process Glycogen Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs		Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1	4 interactors: APP COPS6 NEDD4L POLA2
Entrez ID		23649	83931
HPRD ID		10160	11359
Ensembl ID			ENSG00000196182
Uniprot IDs		Q14181	Q8N2I9
PDB IDs		2KEB 4E2I
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport	Cellular Homeostasis Positive Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cullin Deneddylation Regulation Of Tight Junction Assembly Neuron Remodeling Cellular Metal Ion Homeostasis Negative Regulation Of Sodium Ion Transport Protein Deneddylation Cellular Cation Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Sodium Ion Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ventricular Cardiac Muscle Cell Action Potential Cellular Copper Ion Homeostasis Viral Process Ion Homeostasis Regulation Of Protein Localization To Cell Surface Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Potassium Ion Transport Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Repolarization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Copper Ion Homeostasis Suckling Behavior Nuclear DNA Replication Telomere Maintenance Via Recombination Sodium Ion Homeostasis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Potassium Ion Transmembrane Transporter Activity Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Sodium Ion Transmembrane Transporter Activity Protein Import Into Nucleus, Translocation Neuron Maturation MRNA Polyadenylation
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp	accordingly acting collectively documented downregulates e2f2 escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp	accordingly acting collectively documented downregulates e2f2 escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate subgroup supporting suppressive te undetectable upstream virtually
Tagcloud (Intersection) ?