POLA2 and NHP2L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	NHP2L1
Gene Name		polymerase (DNA directed), alpha 2, accessory subunit	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Box C/D SnoRNP Complex Protein Complex
	Molecular Function	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity Protein Heterodimerization Activity	RNA Binding Protein Binding SnoRNA Binding Poly(A) RNA Binding
	Biological Process	Protein Import Into Nucleus, Translocation G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Ribosome Biogenesis
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs		Dacarbazine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKTIP APP ASCC2 ATP5C1 CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 NHP2L1 NR4A1 PARP1 POLA1 PRPF38A RBM23 SETDB1 STK40 ULK2 XPNPEP1	14 interactors: CDKN2C CHST1 GTF3C1 LRIF1 MAP1LC3B POLA2 PPIH PRPF3 PRPF31 PRPF4 RAD17 RBM10 SNW1 XRCC6
Entrez ID		23649	4809
HPRD ID		10160	03197
Ensembl ID			ENSG00000100138
Uniprot IDs		Q14181	P55769 Q6FHM6
PDB IDs		2KEB 4E2I	1E7K 2JNB 2OZB 3SIU 3SIV
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Developmental Growth Growth MRNA Metabolic Process DNA Replication, Synthesis Of RNA Primer Regulation Of Growth Cellular Response To Reactive Oxygen Species Regulation Of Binding Regulation Of Receptor Activity Organ Development Metabolic Process RNA Processing Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Developmental Growth Involved In Morphogenesis Regulation Of Protein Binding Positive Regulation Of Cell Death Histone H3-K9 Modification Negative Regulation Of Epithelial Cell Differentiation Cellular Protein Modification Process Cellular Protein Metabolic Process Chromosome Organization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Hepatocyte Differentiation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Hsp90 Deacetylation Response To Oxidative Stress MRNA Processing RNA Biosynthetic Process Cochlea Development Response To Reactive Oxygen Species Negative Regulation Of Cell Differentiation Cellular Response To Oxidative Stress Lung Alveolus Development Macroautophagy Regulation Of Cell Differentiation System Development Cellular Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly RNA Metabolic Process Gene Expression Cellular Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Viral Process Telomere Maintenance Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Hyperosmotic Salinity Response Macromolecule Biosynthetic Process 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Cellular Response To X-ray Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle TRNA Transcription Ribonucleoprotein Complex Assembly Establishment Of Integrated Proviral Latency Metabolic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Positive Regulation By Host Of Viral Transcription Mitotic Cell Cycle Process DNA Replication Checkpoint Cellular Response To Salt Stress DNA Recombination Mitotic Cell Cycle DNA Ligation
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pold1 prpf19 recq5 sensitize smrp sparcl1 transendothelial ts tymp
Tagcloud (Intersection) ?