POLA2 and DHX34

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		POLA2	DHX34
Description		DNA polymerase alpha 2, accessory subunit	DExH-box helicase 34
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol Ciliary Basal Body	Membrane
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation Protein Import Into Nucleus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Dacarbazine
Diseases
GWAS		Acne (severe) ( 24927181) Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		33 interacting genes: AKTIP APP ASCC2 ATP5F1C CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SETDB1 SNU13 STK40 ULK2 XPNPEP1	4 interacting genes: GSK3B POLA2 RNF10 RPS6KA6
Entrez ID		23649	9704
HPRD ID		10160	13144
Ensembl ID		ENSG00000014138	ENSG00000134815
Uniprot IDs		A0A9L9PY44 H0YDR7 Q14181	Q14147
PDB IDs		2KEB 4E2I 4Y97 5EXR 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		DNA Replication, Synthesis Of Primer Regulation Of Phosphorus Metabolic Process Nucleic Acid Metabolic Process Collateral Sprouting RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Macromolecule Metabolic Process Alpha DNA Polymerase:primase Complex Regulation Of Glycolytic Process	Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Multicellular Organismal Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of Developmental Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Development Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Localization To Centrosome Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer Negative Regulation Of Embryonic Development Ribosomal Protein S6 Kinase Activity Regulation Of Mesoderm Development Negative Regulation Of Mesoderm Development Negative Regulation Of Glycogen Biosynthetic Process ER Overload Response Protein Serine Kinase Activity Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Mesenchymal Stem Cell Differentiation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Beta-catenin Destruction Complex Wnt Signalosome Regulation Of Protein Localization To Centrosome Regulation Of Cellular Response To Heat Maintenance Of Cell Polarity Regulation Of TORC2 Signaling Protein Kinase A Catalytic Subunit Binding Protein Serine/threonine Kinase Activity Dynactin Binding Transferase Activity Negative Regulation Of Glial Cell Proliferation Proteasomal Protein Catabolic Process
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