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POLA2
Description
DNA polymerase alpha 2, accessory subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Cytosol
Ciliary Basal Body
Molecular Function
DNA Binding
Protein Binding
Biological Process
DNA Replication
DNA Replication, Synthesis Of Primer
DNA Replication Initiation
Protein Import Into Nucleus
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
DNA replication initiation
Activation of the pre-replicative complex
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Defective pyroptosis
Drugs
Dacarbazine
Diseases
GWAS
Acne (severe) (
24927181
)
Appendicular lean mass (
33097823
)
Hip circumference adjusted for BMI (
34021172
)
Serum uric acid levels (
32514006
)
Novel Interacting Genes
8 novel interacting genes:
AGO2
ARL2
ATL3
CATSPERZ
KDM2A
SAC3D1
TMEM216
ZNRD2
Interacting Genes
33 interacting genes:
AKTIP
APP
ASCC2
ATP5F1C
CPE
CRELD1
DCP2
DDX24
DHX34
EIF6
EZH2
FAM219A
FGFR3
FRZB
HDAC6
HELB
HGH1
IGFBP3
KCNE3
KLF6
LRPAP1
MFHAS1
NR4A1
PARP1
POLA1
PRIM2
PRPF38A
RBM23
SETDB1
SNU13
STK40
ULK2
XPNPEP1
Entrez ID
23649
HPRD ID
10160
Ensembl ID
ENSG00000014138
Uniprot IDs
A0A9L9PY44
H0YDR7
Q14181
PDB IDs
2KEB
4E2I
4Y97
5EXR
7OPL
7U5C
8B9D
8D0B
8D0K
8D9D
8QJ7
8VY3
9C8V
Enriched GO Terms of Interacting Partners
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DNA Replication, Synthesis Of Primer
Regulation Of Phosphorus Metabolic Process
Nucleic Acid Metabolic Process
Collateral Sprouting
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of ATP Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Macromolecule Metabolic Process
Alpha DNA Polymerase:primase Complex
Regulation Of Glycolytic Process
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