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POLA2 and PRPF38A
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
POLA2
PRPF38A
Gene Name
polymerase (DNA directed), alpha 2, accessory subunit
pre-mRNA processing factor 38A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Cytoplasm
Nucleus
Nuclear Membrane
Precatalytic Spliceosome
Molecular Function
Molecular_function
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Heterodimerization Activity
Protein Binding
Poly(A) RNA Binding
Biological Process
Protein Import Into Nucleus, Translocation
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
MRNA Processing
RNA Splicing
Pathways
Activation of the pre-replicative complex
Extension of Telomeres
Activation of the pre-replicative complex
Leading Strand Synthesis
DNA strand elongation
Polymerase switching
DNA replication initiation
Telomere Maintenance
G1/S Transition
Mitotic G1-G1/S phases
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Telomere C-strand synthesis initiation
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the lagging strand
DNA Replication Pre-Initiation
M/G1 Transition
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Cell Cycle, Mitotic
Removal of the Flap Intermediate
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Dacarbazine
Diseases
GWAS
Protein-Protein Interactions
31 interactors:
AKTIP
APP
ASCC2
ATP5C1
CPE
CRELD1
DCP2
DDX24
DHX34
EIF6
EZH2
FAM219A
FGFR3
FRZB
HDAC6
HELB
HGH1
IGFBP3
KCNE3
KLF6
LRPAP1
NHP2L1
NR4A1
PARP1
POLA1
PRPF38A
RBM23
SETDB1
STK40
ULK2
XPNPEP1
21 interactors:
APP
CHERP
CLK2
CSNK2A1
DHX8
GTF3C1
JMJD6
MAPK6
POLA2
PPIG
PRMT5
RBM39
RNPS1
SDCBP
SDCBP2
SRPK1
SRPK2
SRSF3
SRSF4
U2AF1
ZCCHC10
Entrez ID
23649
84950
HPRD ID
10160
10972
Ensembl ID
Uniprot IDs
Q14181
Q8NAV1
PDB IDs
2KEB
4E2I
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Developmental Growth
Growth
MRNA Metabolic Process
DNA Replication, Synthesis Of RNA Primer
Regulation Of Growth
Cellular Response To Reactive Oxygen Species
Regulation Of Binding
Regulation Of Receptor Activity
Organ Development
Metabolic Process
RNA Processing
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Cell Development
Positive Regulation Of Programmed Cell Death
Developmental Growth Involved In Morphogenesis
Regulation Of Protein Binding
Positive Regulation Of Cell Death
Histone H3-K9 Modification
Negative Regulation Of Epithelial Cell Differentiation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Chromosome Organization
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Hepatocyte Differentiation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Hsp90 Deacetylation
Response To Oxidative Stress
MRNA Processing
RNA Biosynthetic Process
Cochlea Development
Response To Reactive Oxygen Species
Negative Regulation Of Cell Differentiation
Cellular Response To Oxidative Stress
Lung Alveolus Development
Macroautophagy
Regulation Of Cell Differentiation
System Development
Cellular Response To Hydrogen Peroxide
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Leading Strand Elongation
Synaptic Growth At Neuromuscular Junction
Polyubiquitinated Misfolded Protein Transport
RNA Processing
RNA Splicing
MRNA Processing
MRNA Metabolic Process
Regulation Of RNA Splicing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
Gene Expression
Regulation Of MRNA Splicing, Via Spliceosome
MRNA 3'-end Processing
Nucleobase-containing Compound Metabolic Process
Regulation Of MRNA Processing
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA 3'-end Processing
Cellular Nitrogen Compound Metabolic Process
Termination Of RNA Polymerase II Transcription
Nitrogen Compound Metabolic Process
MRNA Export From Nucleus
DNA-templated Transcription, Termination
RNA Export From Nucleus
Intracellular Transport
Nucleocytoplasmic Transport
Nuclear Transport
Nuclear Export
MRNA Transport
RNA Transport
RNA Localization
Establishment Of Localization In Cell
Cellular Metabolic Process
Cytoplasmic Transport
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Localization
Negative Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of RNA Splicing
Positive Regulation Of Viral Genome Replication
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Protein Phosphorylation
Cellular Protein Modification Process
Negative Regulation Of Viral Genome Replication
Nuclear Speck Organization
Histone H3-R2 Demethylation
Histone H4-R3 Demethylation
Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine
Regulation Of RNA Metabolic Process
Regulation Of Viral Genome Replication
Positive Regulation Of Viral Process
Tagcloud
?
beadchip
ca125
carboplatin
cdkn1b
chek2
ck7
cyfra21
cytokinesis
deserve
exceptional
fancd2
illumina
krt7
lig3
mesothelioma
nt5c
obscure
pemetrexed
phosphorylase
platinum
pold1
prpf19
recq5
sensitize
smrp
sparcl1
transendothelial
ts
tymp
Tagcloud (Difference)
?
beadchip
ca125
carboplatin
cdkn1b
chek2
ck7
cyfra21
cytokinesis
deserve
exceptional
fancd2
illumina
krt7
lig3
mesothelioma
nt5c
obscure
pemetrexed
phosphorylase
platinum
pold1
prpf19
recq5
sensitize
smrp
sparcl1
transendothelial
ts
tymp
Tagcloud (Intersection)
?