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HLA-DMB and MDM2
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
HLA-DMB
MDM2
Gene Name
major histocompatibility complex, class II, DM beta
MDM2 proto-oncogene, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Lysosomal Membrane
Integral Component Of Membrane
Late Endosome Membrane
MHC Class II Protein Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Endocytic Vesicle Membrane
Protein Complex
Synapse
Molecular Function
MHC Class II Protein Complex Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Peroxisome Proliferator Activated Receptor Binding
Ubiquitin Protein Ligase Activity
Scaffold Protein Binding
Biological Process
MHC Class II Protein Complex Assembly
Peptide Antigen Assembly With MHC Class II Protein Complex
Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of T Cell Proliferation
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Protein Complex Assembly
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Traversing Start Control Point Of Mitotic Cell Cycle
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Carbohydrate
Response To Iron Ion
Positive Regulation Of Gene Expression
Viral Process
Protein Ubiquitination
Peptidyl-lysine Modification
Protein Destabilization
Response To Magnesium Ion
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Response To Cocaine
Response To Drug
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Morphine
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Innate Immune Response
Establishment Of Protein Localization
Response To Ether
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Cellular Response To Hydrogen Peroxide
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Acid Chemical
Cellular Response To Antibiotic
Cellular Response To Vitamin B1
Cellular Response To Alkaloid
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Hypoxia
Cellular Response To UV-C
Pathways
MHC class II antigen presentation
Adaptive Immune System
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Cellular Senescence
p53-Dependent G1/S DNA damage checkpoint
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
Stabilization of p53
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Transmission across Chemical Synapses
PIP3 activates AKT signaling
Oncogene Induced Senescence
p53-Dependent G1 DNA Damage Response
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
G1/S DNA Damage Checkpoints
Innate Immune System
Signalling by NGF
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Trafficking of AMPA receptors
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
Oxidative Stress Induced Senescence
Cell Cycle Checkpoints
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
CD63
CD74
CD82
CUL3
DPM2
HLA-DMA
HLA-DOB
HLA-DRA
MDM2
TEAD1
185 interactors:
ABL1
ADRB2
ADRBK1
AKT1
ANKRD17
APEX1
APP
AR
ARRB2
ATF3
ATF4
ATM
ATP2A2
AURKA
BAIAP2L1
BRINP1
BTRC
CANX
CASP2
CASP3
CCAR1
CCNG1
CDH1
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DHFR
DLG4
DNAJB4
DYRK2
E2F1
EID1
EP300
ESR1
EZR
FOXO1
G3BP2
GADD45A
GCAT
GLTSCR2
GNL3
GORAB
GSK3B
GTF2E1
GTF2E2
HDAC1
HIF1A
HIPK2
HIST2H2BE
HIST3H3
HLA-DMB
HRSP12
HSP90B1
IGF1R
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
LMO7
MDM4
MED1
MKRN3
MS4A1
MTBP
MYD88
MYDGF
NACA
NCL
NOTCH1
NPM1
NR3C1
NUMB
PAK6
PBX1
PDE4D
PDIA3
PDLIM7
PGAM2
PHF7
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RABL6
RAD23A
RANBP1
RANBP2
RASSF1
RB1
RBM38
RCHY1
RNF10
RNF126
RNF8
RPL11
RPL26
RPL5
RPS23
RPS27A
RPS3
RPS7
RRM2B
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SENP3
SESN2
SET
SETDB1
SHPK
SMARCA2
SMARCA4
SMARCE1
SORBS2
SREK1
SRSF11
SUMO1
TAF1
TBP
TCAP
TERT
TOP1
TP53
TP73
TPR
TPT1
TRAF5
TRIM23
TRIM27
TRIM4
TRIM9
TSC22D3
TSG101
UBB
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2L3
UBE2M
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP2
USP7
WT1
XPC
YY1AP1
ZNF133
Entrez ID
3109
4193
HPRD ID
00831
01272
Ensembl ID
ENSG00000242574
ENSG00000135679
Uniprot IDs
P28068
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
PDB IDs
1HDM
2BC4
4FQX
4GBX
4I0P
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4JV7
4JV9
4JVE
4JVR
4JWR
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Antigen Processing And Presentation
Positive Thymic T Cell Selection
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Complex Assembly
Thymic T Cell Selection
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Chaperone Mediated Protein Folding Requiring Cofactor
Positive T Cell Selection
Immune Response
Regulation Of Immune System Process
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
T Cell Selection
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Immune Response
'de Novo' Posttranslational Protein Folding
Positive Regulation Of Cell Cycle Phase Transition
'de Novo' Protein Folding
Chaperone-mediated Protein Folding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Differentiation In Thymus
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Cellular Component Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Lymphocyte Activation
Macrophage Migration Inhibitory Factor Signaling Pathway
Cellular Response To UV-C
Cellular Response To Vitamin B1
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Immune System Process
Regulation Of Cell Activation
Polysaccharide Assembly With MHC Class II Protein Complex
Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Mitotic Cell Cycle
Regulation Of T Cell Differentiation
Regulation Of Response To DNA Damage Stimulus
Regulation Of Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Stress
Viral Process
Cell Cycle Process
Cell Cycle
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Cell Death
Death
Programmed Cell Death
Protein Modification By Small Protein Conjugation
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Protein Metabolic Process
Apoptotic Process
Regulation Of Apoptotic Process
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Death
Regulation Of Cell Cycle Phase Transition
Protein Ubiquitination
Regulation Of Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Protein Polyubiquitination
Positive Regulation Of Cell Cycle
Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Mitotic Cell Cycle
Positive Regulation Of Cell Cycle Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Tagcloud
?
abundance
bound
cbp
coactivator
destabilizer
directed
e1a
endogenous
h1
implies
implying
interactions
intimately
naturally
normally
occurring
operate
overproducing
p300
p53
regard
serves
stability
stabilizing
steps
taken
translates
turnover
underscored
Tagcloud (Difference)
?
abundance
bound
cbp
coactivator
destabilizer
directed
e1a
endogenous
h1
implies
implying
interactions
intimately
naturally
normally
occurring
operate
overproducing
p300
p53
regard
serves
stability
stabilizing
steps
taken
translates
turnover
underscored
Tagcloud (Intersection)
?