HLA-DMB and HLA-DOB

Number of citations of the paper that reports this interaction (PubMedID 9311912)
0

Data Source:
HPRD (in vivo)

		HLA-DMB	HLA-DOB
Description		major histocompatibility complex, class II, DM beta	major histocompatibility complex, class II, DO beta
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane MHC Class II Protein Complex	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding	MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		MHC class II antigen presentation	MHC class II antigen presentation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Bullous pemphigoid ( 34011352) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Kawasaki disease ( 22446962 33106546) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte count ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730) Takayasu arteritis ( 25604533) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1	2 interacting genes: CDKN2A HLA-DMB
Entrez ID		3109	3112
HPRD ID		00831	08368
Ensembl ID		ENSG00000242574	ENSG00000241106
Uniprot IDs		A0A1V0E3P2 P28068	P13765 Q5QNS2
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P	4I0P
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Peptide Antigen Binding Late Endosome Membrane Lysosomal Membrane Protein-containing Complex Assembly Protein-containing Complex Organization Lysosome Positive Regulation Of Cell Adhesion Endocytic Vesicle Membrane MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Endosome Regulation Of Cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Antigen Processing And Presentation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Cellular Component Assembly Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Multivesicular Body Transport Vesicle Membrane Pigment Granule Maturation Cell Surface MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Regulation Of Cell Activation Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Immune Response ER To Golgi Transport Vesicle Membrane	Positive Regulation Of Macrophage Apoptotic Process Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of T Cell Activation Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Ligase Inhibitor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell MHC Class II Protein Complex Assembly Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Ubiquitin Protein Ligase Activity Mitochondrial Depolarization Oncogene-induced Cell Senescence Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Involved In Development Somatic Stem Cell Division Protein Localization To Nucleolus Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis MDM2/MDM4 Family Protein Binding Regulation Of Lymphocyte Activation Ubiquitin Ligase Inhibitor Activity Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell-cell Adhesion Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Protein Sumoylation Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replicative Senescence Mammary Gland Epithelial Cell Proliferation MHC Class II Protein Complex Peptide Antigen Assembly With MHC Class II Protein Complex Negative Regulation Of B Cell Proliferation Nuclear Body Organization Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cell Adhesion SUMO Transferase Activity Regulation Of Protein Neddylation Stem Cell Division
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