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HLA-DMB and HLA-DRA
Number of citations of the paper that reports this interaction (PMID
7648393
)
69
Data Source:
HPRD
(in vivo, in vitro)
HLA-DMB
HLA-DRA
Gene Name
major histocompatibility complex, class II, DM beta
major histocompatibility complex, class II, DR alpha
Image
Gene Ontology Annotations
Cellular Component
Lysosomal Membrane
Integral Component Of Membrane
Late Endosome Membrane
MHC Class II Protein Complex
Golgi Membrane
Lysosome
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Late Endosome Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
MHC Class II Protein Complex Binding
MHC Class II Protein Complex Binding
MHC Class II Receptor Activity
Peptide Antigen Binding
Biological Process
MHC Class II Protein Complex Assembly
Peptide Antigen Assembly With MHC Class II Protein Complex
Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of T Cell Proliferation
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Peptide Antigen Assembly With MHC Class II Protein Complex
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Polysaccharide Assembly With MHC Class II Protein Complex
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Cognition
Interferon-gamma-mediated Signaling Pathway
Pathways
MHC class II antigen presentation
Adaptive Immune System
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Anti-cyclic Citrullinated Peptide Antibody (
19287509
)
Asthma (
23028483
21804548
)
Complement C3 and C4 levels (
23028341
)
Cystic fibrosis severity (
21602797
)
Hodgkin's lymphoma (
21037568
22286212
)
Lymphoma (
23349640
)
Multiple sclerosis (
17660530
)
Multiple sclerosis (OCB status) (
23472185
)
Non-obstructive azoospermia (
22541561
)
Parkinson's disease (
20711177
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Rheumatoid arthritis (
21653640
)
Systemic sclerosis (
21779181
)
Ulcerative colitis (
23128233
20228798
18836448
21297633
19122664
)
Vitiligo (
20410501
)
Protein-Protein Interactions
10 interactors:
CD63
CD74
CD82
CUL3
DPM2
HLA-DMA
HLA-DOB
HLA-DRA
MDM2
TEAD1
10 interactors:
CD63
CD74
CD82
HLA-DMA
HLA-DMB
HLA-DRB1
HLA-DRB5
MARCH1
MBP
PRPF40B
Entrez ID
3109
3122
HPRD ID
00831
00833
Ensembl ID
ENSG00000242574
ENSG00000204287
Uniprot IDs
P28068
P01903
Q30118
PDB IDs
1HDM
2BC4
4FQX
4GBX
4I0P
1A6A
1AQD
1BX2
1D5M
1D5X
1D5Z
1D6E
1DLH
1FV1
1FYT
1H15
1HQR
1HXY
1J8H
1JWM
1JWS
1JWU
1KG0
1KLG
1KLU
1LO5
1PYW
1R5I
1SEB
1SJE
1SJH
1T5W
1T5X
1YMM
1ZGL
2FSE
2G9H
2IAM
2IAN
2ICW
2IPK
2OJE
2Q6W
2SEB
2WBJ
2XN9
3C5J
3L6F
3O6F
3PDO
3PGC
3PGD
3QXA
3QXD
3S4S
3S5L
3T0E
4AEN
4AH2
4E41
4FQX
4GBX
4H1L
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Antigen Processing And Presentation
Positive Thymic T Cell Selection
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Complex Assembly
Thymic T Cell Selection
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Chaperone Mediated Protein Folding Requiring Cofactor
Positive T Cell Selection
Immune Response
Regulation Of Immune System Process
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
T Cell Selection
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Immune Response
'de Novo' Posttranslational Protein Folding
Positive Regulation Of Cell Cycle Phase Transition
'de Novo' Protein Folding
Chaperone-mediated Protein Folding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Differentiation In Thymus
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Cellular Component Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Lymphocyte Activation
Macrophage Migration Inhibitory Factor Signaling Pathway
Cellular Response To UV-C
Cellular Response To Vitamin B1
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Immune System Process
Regulation Of Cell Activation
Polysaccharide Assembly With MHC Class II Protein Complex
Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Mitotic Cell Cycle
Regulation Of T Cell Differentiation
Regulation Of Response To DNA Damage Stimulus
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Antigen Processing And Presentation
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Immune Response
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Regulation Of Cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Positive Thymic T Cell Selection
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Thymic T Cell Selection
Immunoglobulin Mediated Immune Response
B Cell Mediated Immunity
Chaperone Mediated Protein Folding Requiring Cofactor
Positive T Cell Selection
Regulation Of Immune System Process
Regulation Of Interleukin-4 Production
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Response To Cytokine
Leukocyte Mediated Immunity
T Cell Selection
Adaptive Immune Response
'de Novo' Posttranslational Protein Folding
'de Novo' Protein Folding
Cellular Protein Complex Assembly
Chaperone-mediated Protein Folding
T Cell Costimulation
T Cell Differentiation In Thymus
Protein Complex Assembly
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Macrophage Migration Inhibitory Factor Signaling Pathway
Positive Regulation Of T Cell Differentiation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Negative Regulation Of Leukocyte Cell-cell Adhesion
T Cell Receptor Signaling Pathway
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