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HLA-DMB and DPM2
Number of citations of the paper that reports this interaction (PMID
11591653
)
37
Data Source:
HPRD
(in vivo)
HLA-DMB
DPM2
Gene Name
major histocompatibility complex, class II, DM beta
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Lysosomal Membrane
Integral Component Of Membrane
Late Endosome Membrane
MHC Class II Protein Complex
Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex
Endoplasmic Reticulum Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Dolichol-phosphate-mannose Synthase Complex
Perinuclear Region Of Cytoplasm
Molecular Function
MHC Class II Protein Complex Binding
Dolichyl-phosphate Beta-D-mannosyltransferase Activity
Protein Binding
Enzyme Regulator Activity
Biological Process
MHC Class II Protein Complex Assembly
Peptide Antigen Assembly With MHC Class II Protein Complex
Immune Response
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of T Cell Proliferation
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Dolichol-linked Oligosaccharide Biosynthetic Process
C-terminal Protein Lipidation
GPI Anchor Biosynthetic Process
Preassembly Of GPI Anchor In ER Membrane
Protein N-linked Glycosylation Via Asparagine
Dolichol Metabolic Process
Regulation Of Protein Stability
Protein O-linked Mannosylation
Post-translational Protein Modification
Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Pathways
MHC class II antigen presentation
Adaptive Immune System
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective MOGS causes MOGS-CDG (CDG-2b)
Synthesis of glycosylphosphatidylinositol (GPI)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Synthesis of dolichyl-phosphate mannose
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Post-translational modification: synthesis of GPI-anchored proteins
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Synthesis of dolichyl-phosphate mannose
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
10 interactors:
CD63
CD74
CD82
CUL3
DPM2
HLA-DMA
HLA-DOB
HLA-DRA
MDM2
TEAD1
6 interactors:
DPM1
DPM3
HLA-DMB
PIGA
PIGC
VKORC1
Entrez ID
3109
8818
HPRD ID
00831
16028
Ensembl ID
ENSG00000242574
ENSG00000136908
Uniprot IDs
P28068
O94777
PDB IDs
1HDM
2BC4
4FQX
4GBX
4I0P
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Antigen Processing And Presentation
Positive Thymic T Cell Selection
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Complex Assembly
Thymic T Cell Selection
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Chaperone Mediated Protein Folding Requiring Cofactor
Positive T Cell Selection
Immune Response
Regulation Of Immune System Process
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
T Cell Selection
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Immune Response
'de Novo' Posttranslational Protein Folding
Positive Regulation Of Cell Cycle Phase Transition
'de Novo' Protein Folding
Chaperone-mediated Protein Folding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
T Cell Differentiation In Thymus
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Cellular Component Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Lymphocyte Activation
Macrophage Migration Inhibitory Factor Signaling Pathway
Cellular Response To UV-C
Cellular Response To Vitamin B1
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Immune System Process
Regulation Of Cell Activation
Polysaccharide Assembly With MHC Class II Protein Complex
Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Mitotic Cell Cycle
Regulation Of T Cell Differentiation
Regulation Of Response To DNA Damage Stimulus
C-terminal Protein Lipidation
Post-translational Protein Modification
GPI Anchor Biosynthetic Process
GPI Anchor Metabolic Process
Glycolipid Biosynthetic Process
Protein Lipidation
Lipoprotein Biosynthetic Process
Phosphatidylinositol Biosynthetic Process
Glycolipid Metabolic Process
Lipoprotein Metabolic Process
Glycerophospholipid Biosynthetic Process
Phosphatidylinositol Metabolic Process
Membrane Lipid Metabolic Process
Phospholipid Biosynthetic Process
Glycerophospholipid Metabolic Process
Glycerolipid Metabolic Process
Phospholipid Metabolic Process
Protein O-linked Mannosylation
Lipid Biosynthetic Process
Preassembly Of GPI Anchor In ER Membrane
Protein Mannosylation
Mannosylation
Cellular Lipid Metabolic Process
Organophosphate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Lipid Metabolic Process
Protein O-linked Glycosylation
Cellular Protein Modification Process
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Protein N-linked Glycosylation Via Asparagine
Protein N-linked Glycosylation
Dolichol Metabolic Process
Cellular Protein Metabolic Process
Peptidyl-amino Acid Modification
Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Vitamin K Metabolic Process
Phosphate-containing Compound Metabolic Process
Macromolecule Glycosylation
Protein Glycosylation
Glycosylation
Protein Metabolic Process
Peptidyl-glutamic Acid Carboxylation
Glycoprotein Biosynthetic Process
Glycoprotein Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
GDP-mannose Metabolic Process
Quinone Metabolic Process
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