HLA-DMB and CD63

Number of citations of the paper that reports this interaction (PMID 9759843)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HLA-DMB	CD63
Gene Name		major histocompatibility complex, class II, DM beta	CD63 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Melanosome Extracellular Vesicular Exosome Multivesicular Body, Internal Vesicle
	Molecular Function	MHC Class II Protein Complex Binding	Protein Binding
	Biological Process	MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Protein Transport Cell Migration Platelet Activation Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Rubidium Ion Transport Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		MHC class II antigen presentation Adaptive Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 TEAD1	13 interactors: AP4M1 CD82 CD9 HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1
Entrez ID		3109	967
HPRD ID		00831	01121
Ensembl ID		ENSG00000242574	ENSG00000135404
Uniprot IDs		P28068	P08962
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Positive Thymic T Cell Selection Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Complex Assembly Thymic T Cell Selection Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Immune Response Regulation Of Immune System Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Selection Regulation Of Signal Transduction By P53 Class Mediator Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Immune Response 'de Novo' Posttranslational Protein Folding Positive Regulation Of Cell Cycle Phase Transition 'de Novo' Protein Folding Chaperone-mediated Protein Folding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cellular Component Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Lymphocyte Activation Macrophage Migration Inhibitory Factor Signaling Pathway Cellular Response To UV-C Cellular Response To Vitamin B1 Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Immune System Process Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Mitotic Cell Cycle Regulation Of T Cell Differentiation Regulation Of Response To DNA Damage Stimulus	Wound Healing Response To Wounding Blood Coagulation Positive Regulation Of Extracellular Vesicular Exosome Assembly Hemostasis Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Extracellular Vesicular Exosome Assembly MHC Class II Protein Complex Assembly Regulation Of Body Fluid Levels Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Organelle Assembly Platelet Activation Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Myoblast Differentiation Cell Activation Positive Regulation Of Exocytosis Positive Regulation Of Cellular Component Biogenesis Response To Stress Basophil Degranulation Contractile Actin Filament Bundle Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Exocytosis Platelet Degranulation Response To Stimulus Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Basophil Activation Polysaccharide Assembly With MHC Class II Protein Complex Myoblast Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Trophoblast Cell Migration Cell-cell Junction Assembly Secretion By Cell Establishment Of Localization In Cell Odontogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Exocytosis Immune System Process Striated Muscle Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose
Tagcloud ?			acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated
Tagcloud (Difference) ?			acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated
Tagcloud (Intersection) ?