HIF1AN and ANKRD50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HIF1AN	ANKRD50
Description		hypoxia inducible factor 1 subunit alpha inhibitor	ankyrin repeat domain containing 50
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Endosome
	Molecular Function	Transcription Corepressor Activity Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity [protein]-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Metal Ion Binding NF-kappaB Binding Dioxygenase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Ankyrin Repeat Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Vasculogenesis	Protein Transport Endocytic Recycling
Pathways		Cellular response to hypoxia
Drugs		D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293)	Cerebrospinal fluid AB1-42 levels ( 26252872) Gastric cancer ( 31383772) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Metabolite levels ( 23823483) Small vessel stroke ( 29123153) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		17 interacting genes: ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL	8 interacting genes: ANKRD28 APP CLNK HIF1AN PEX5 SMURF1 ZDHHC17 ZNF250
Entrez ID		55662	57182
HPRD ID		09426	13843
Ensembl ID		ENSG00000166135	ENSG00000151458
Uniprot IDs		Q9NWT6	Q8TB46 Q9ULJ7
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S 8IHZ 8II0 8K71 8K72 8K73 9FSN 9IIF
Enriched GO Terms of Interacting Partners?		Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity NF-kappaB Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Protein De-2-hydroxyisobutyrylase Activity Enzyme Binding Fungiform Papilla Formation Protein Modification Process Histone Deacetylase Binding Hair Follicle Placode Formation Histone Deacetylase Complex Transcription Corepressor Binding Cytosol DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Deacetylase Activity P53 Binding Protein Deacetylation Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Cul5-RING Ubiquitin Ligase Complex NuRD Complex Protein Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Regulation Of Apoptotic Process Protein Ubiquitination Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Circadian Rhythm Regulation Of Programmed Cell Death Heterochromatin Formation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of TOR Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Intracellular Signal Transduction	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Receptor Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Perforant Pathway To Dendrate Granule Cell Synapse [protein]-asparagine 3-dioxygenase Activity Engulfment Of Target By Autophagosome Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity Regulation Of Growth Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Positive Regulation Of Developmental Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Axonogenesis Low-density Lipoprotein Particle Mediated Signaling Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Protein-cysteine S-myristoyltransferase Activity Oxygen Sensor Activity Mast Cell Granule
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