HIF1AN and ASB9

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		HIF1AN	ASB9
Gene Name		hypoxia inducible factor 1, alpha subunit inhibitor	ankyrin repeat and SOCS box containing 9
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Mitochondrion
	Molecular Function	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding	Protein Binding
	Biological Process	Transcription, DNA-templated Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Vasculogenesis	Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of Protein Catabolic Process
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		13 interactors: ASB13 ASB4 ASB9 FBF1 FEM1B HDAC1 HDAC2 HDAC3 HIF1A INVS NFKB1 UACA VHL	4 interactors: CKB CKM HIF1AN UBE2D1
Entrez ID		55662	140462
HPRD ID		09426	06452
Ensembl ID			ENSG00000102048
Uniprot IDs		Q9NWT6	Q96DX5
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO	3D9H 3ZKJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Biosynthetic Process Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Negative Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Deacetylation Negative Regulation Of Programmed Cell Death Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Fungiform Papilla Formation Circadian Regulation Of Gene Expression Protein Ubiquitination Fungiform Papilla Morphogenesis Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Signaling Hair Follicle Placode Formation Regulation Of Signal Transduction Tongue Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Maturation Notch Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Differentiation Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Signaling Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Communication Circadian Rhythm Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Tongue Development Epithelial Cell Differentiation Positive Regulation Of Cellular Metabolic Process Epithelium Development	Creatine Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Peptidyl-asparagine Hydroxylation Phosphocreatine Biosynthetic Process Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Response To Hypoxia Cellular Chloride Ion Homeostasis Chloride Ion Homeostasis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Vasculogenesis Cellular Amino Acid Metabolic Process Regulation Of Vasculogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Myoblast Differentiation Protein Hydroxylation Negative Regulation Of Notch Signaling Pathway Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein K48-linked Ubiquitination Substantia Nigra Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Myoblast Differentiation Anion Homeostasis Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Neural Nucleus Development Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Notch Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Carboxylic Acid Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Proteasomal Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Difference) ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Intersection) ?