HIF1AN and ASB4

Number of citations of the paper that reports this interaction (PMID 17636018)
19

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo)

		HIF1AN	ASB4
Gene Name		hypoxia inducible factor 1, alpha subunit inhibitor	ankyrin repeat and SOCS box containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding	Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding
	Biological Process	Transcription, DNA-templated Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Vasculogenesis	Intracellular Signal Transduction Protein Autoubiquitination Positive Regulation Of Vasculogenesis
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		13 interactors: ASB13 ASB4 ASB9 FBF1 FEM1B HDAC1 HDAC2 HDAC3 HIF1A INVS NFKB1 UACA VHL	3 interactors: HIF1AN ID2 UBE2D1
Entrez ID		55662	51666
HPRD ID		09426	05770
Ensembl ID			ENSG00000005981
Uniprot IDs		Q9NWT6	Q9Y574
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Biosynthetic Process Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Negative Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Deacetylation Negative Regulation Of Programmed Cell Death Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Fungiform Papilla Formation Circadian Regulation Of Gene Expression Protein Ubiquitination Fungiform Papilla Morphogenesis Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Signaling Hair Follicle Placode Formation Regulation Of Signal Transduction Tongue Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Maturation Notch Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Differentiation Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Signaling Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Communication Circadian Rhythm Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Tongue Development Epithelial Cell Differentiation Positive Regulation Of Cellular Metabolic Process Epithelium Development	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-histidine Hydroxylation Peptidyl-asparagine Hydroxylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Response To Hypoxia Bundle Of His Development Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Endodermal Digestive Tract Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Transcription, DNA-templated Negative Regulation Of B Cell Differentiation Membranous Septum Morphogenesis RNA Biosynthetic Process Locomotor Rhythm Positive Regulation Of Astrocyte Differentiation Regulation Of Cell Cycle Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Vasculogenesis Cardiac Conduction System Development Enucleate Erythrocyte Differentiation Regulation Of Vasculogenesis Cellular Response To Lithium Ion Circadian Behavior Peyer's Patch Development Positive Regulation Of Myoblast Differentiation Rhythmic Behavior Mitotic Cell Cycle Process RNA Metabolic Process Positive Regulation Of Erythrocyte Differentiation Natural Killer Cell Differentiation Negative Regulation Of Oligodendrocyte Differentiation
Tagcloud ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Difference) ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1
Tagcloud (Intersection) ?