HIF1AN and NAA10

Number of citations of the paper that reports this interaction (PubMedID 30237125)
44

Data Source:
BioGRID (enzymatic study, pull down)

		HIF1AN	NAA10
Description		hypoxia inducible factor 1 subunit alpha inhibitor	N-alpha-acetyltransferase 10, NatA catalytic subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Membrane NatA Complex
	Molecular Function	Transcription Corepressor Activity Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity [protein]-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Metal Ion Binding NF-kappaB Binding Dioxygenase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-aspartic Acid 3-dioxygenase Activity Ankyrin Repeat Binding	Protein-N-terminal Amino-acid Acetyltransferase Activity Protein Binding N-acetyltransferase Activity Protein-N-terminal-alanine Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Ribosome Binding Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Vasculogenesis	Protein Acetylation N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Cellular response to hypoxia
Drugs		D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293)	Systemic lupus erythematosus ( 26502338)
Interacting Genes		17 interacting genes: ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL	59 interacting genes: ACOT12 BAALC BCOR CALCOCO2 CASP8AP2 CCDC106 CCDC174 CDC25A CEBPA CEP44 CFTR CREB3 CREBRF CTNNB1 DDIT4L DHX57 EHMT2 FIP1L1 GPATCH2L H4C1 HIF1A HIF1AN HSPA4 HYPK KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 MCRS1 MDM4 MEOX2 MKRN1 MRPS11 NAA15 NAA16 NAA50 NAT1 NAT2 NOXA1 PDE4DIP PGK1 PLSCR3 PPP2R3B PSME2 RAB3IP RBCK1 RCN3 RIMBP2 RPL26 SEMA3B SNX33 SSX2IP TAF7L TSEN54 UBC ZBTB14 ZNF202 ZNF655
Entrez ID		55662	8260
HPRD ID		09426	02056
Ensembl ID		ENSG00000166135	ENSG00000102030
Uniprot IDs		Q9NWT6	B7Z9N2 P41227
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ 7A1J 7A1K 7A1L 7A1M 7A1N 7A1O 7A1P 7A1Q 7A1S 8IHZ 8II0 8K71 8K72 8K73 9FSN 9IIF	6C95 6C9M 6PPL 6PW9 9F1B 9F1C 9F1D 9FPZ 9FQ0
Enriched GO Terms of Interacting Partners?		Protein Lysine Delactylase Activity Protein Decrotonylase Activity Histone Decrotonylase Activity NF-kappaB Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Protein De-2-hydroxyisobutyrylase Activity Enzyme Binding Fungiform Papilla Formation Protein Modification Process Histone Deacetylase Binding Hair Follicle Placode Formation Histone Deacetylase Complex Transcription Corepressor Binding Cytosol DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Deacetylase Activity P53 Binding Protein Deacetylation Eyelid Development In Camera-type Eye Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Cul5-RING Ubiquitin Ligase Complex NuRD Complex Protein Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Regulation Of Apoptotic Process Protein Ubiquitination Negative Regulation Of Stem Cell Population Maintenance Macromolecule Deacylation Circadian Rhythm Regulation Of Programmed Cell Death Heterochromatin Formation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Amyloid Fibril Formation Regulation Of TOR Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Glial Cell Differentiation Nucleosomal DNA Binding Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Intracellular Signal Transduction	Acetyltransferase Activity NatA Complex Cytosol N-terminal Protein Amino Acid Acetylation Protein Binding Arylamine N-acetyltransferase Activity Nucleus Protein Acetylation
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