HIF1AN and UACA

Number of citations of the paper that reports this interaction (PMID 17003112)
43

Data Source:
BioGRID (two hybrid)

		HIF1AN	UACA
Gene Name		hypoxia inducible factor 1, alpha subunit inhibitor	uveal autoantigen with coiled-coil domains and ankyrin repeats
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Membrane Apoptosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding	Molecular_function Protein Binding
	Biological Process	Transcription, DNA-templated Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Positive Regulation Of Vasculogenesis	Biological_process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Inflammatory Response Regulation Of NIK/NF-kappaB Signaling
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS		Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		13 interactors: ASB13 ASB4 ASB9 FBF1 FEM1B HDAC1 HDAC2 HDAC3 HIF1A INVS NFKB1 UACA VHL	5 interactors: CELSR3 HIF1AN KRT40 MED14 STAMBP
Entrez ID		55662	55075
HPRD ID		09426	11657
Ensembl ID			ENSG00000137831
Uniprot IDs		Q9NWT6	F5H2B9 Q05DB3 Q9BZF9
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Biosynthetic Process Regulation Of Receptor Biosynthetic Process Histone H4 Deacetylation Regulation Of Apoptotic Process Regulation Of Cell Death Histone H3 Deacetylation Histone H3-K9 Modification Histone Deacetylation Negative Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Deacetylation Negative Regulation Of Programmed Cell Death Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Fungiform Papilla Formation Circadian Regulation Of Gene Expression Protein Ubiquitination Fungiform Papilla Morphogenesis Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Signaling Hair Follicle Placode Formation Regulation Of Signal Transduction Tongue Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Maturation Notch Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Differentiation Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Modification Process Signaling Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cell Communication Circadian Rhythm Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Tongue Development Epithelial Cell Differentiation Positive Regulation Of Cellular Metabolic Process Epithelium Development	Peptidyl-asparagine Hydroxylation Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1	accordingly caused contribute deficient elevation empowered fibroblasts genome given guardian harnessed induce inhibit intact mechanistically mutated normal often p53 par paracrine partner resistant secretion selectively sequesters suppressing suppressor systemic
Tagcloud (Difference) ?		bomb coimmunoprecipitation collated cytoskeleton defines depicts dissect evolutionarily fate fih interacted interesting mib mib2 mind notch protease ran screens summarized trabid traf ubiquitin ubiquitylate ubiquitylation usp1 usp9 zebrafish zranb1	accordingly caused contribute deficient elevation empowered fibroblasts genome given guardian harnessed induce inhibit intact mechanistically mutated normal often p53 par paracrine partner resistant secretion selectively sequesters suppressing suppressor systemic
Tagcloud (Intersection) ?