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SOCS7 and TUBA1A
Number of citations of the paper that reports this interaction (PubMedID
12052866
)
44
Data Source:
HPRD
(in vitro)
SOCS7
TUBA1A
Description
suppressor of cytokine signaling 7
tubulin alpha 1a
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cul5-RING Ubiquitin Ligase Complex
Condensed Chromosome
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Axonemal Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Motile Cilium
Neuromuscular Junction
Sperm Flagellum
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Synapse
Recycling Endosome
Extracellular Exosome
Molecular Function
Protein Binding
SH3 Domain Binding
Signaling Adaptor Activity
Phosphorylation-dependent Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Nucleotide Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Protein Ubiquitination
Layer Formation In Cerebral Cortex
Intracellular Signal Transduction
Reelin-mediated Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Neuron Migration
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Neuron Migration
Startle Response
Intracellular Protein Transport
Microtubule-based Process
Centrosome Cycle
Smoothened Signaling Pathway
Memory
Locomotory Behavior
Adult Locomotory Behavior
Visual Learning
Response To Mechanical Stimulus
Glial Cell Differentiation
Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Hippocampus Development
Pyramidal Neuron Differentiation
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Flagellated Sperm Motility
Adult Behavior
Cytoskeleton-dependent Intracellular Transport
Response To Tumor Necrosis Factor
Locomotory Exploration Behavior
Microtubule Polymerization
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Synapse Organization
Synapse Organization
Cell Division
Neuron Apoptotic Process
Motor Behavior
Cellular Response To Calcium Ion
Organelle Transport Along Microtubule
Neuron Projection Arborization
Response To L-glutamate
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Ovarian cancer (
23535730
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
25 interacting genes:
CYSRT1
DAB1
EGFR
EXOSC8
GAS2L2
GRB2
HSPB8
IRS2
IRS4
LENG8
MDFI
MISP
NCK1
NSMF
OSTF1
PIK3R1
PIK3R2
PLCG1
SH3RF1
SORBS2
SORBS3
TNS2
TUBA1A
TUBB4B
YES1
66 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EIF4ENIF1
EML1
ENO1
GEMIN7
GRM7
GSK3B
GZMB
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
OGT
PAFAH1B1
PGK1
PLA2G7
PLK2
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
SYTL4
TAOK2
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
30837
7846
HPRD ID
12299
03959
Ensembl ID
ENSG00000274211
ENSG00000167552
Uniprot IDs
A0A5F9YLF9
O14512
Q71U36
PDB IDs
5JCO
6J8F
6WSL
7C1M
7UN1
7UNG
8J07
8SH7
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Motility
Insulin Receptor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Cell Migration
Enzyme-linked Receptor Protein Signaling Pathway
Protein Phosphatase Binding
Phosphotyrosine Residue Binding
Focal Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Phosphatidylinositol 3-kinase Binding
Cytoskeletal Anchor Activity
Insulin Receptor Binding
Cell Surface Receptor Signaling Pathway
Cytoplasm
Structural Constituent Of Cytoskeleton
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Supramolecular Fiber Organization
Intracellular Signaling Cassette
Natural Killer Cell Mediated Cytotoxicity
Regulation Of MAPK Cascade
1-phosphatidylinositol-3-kinase Regulator Activity
Natural Killer Cell Mediated Immunity
Regulation Of Actin Filament Organization
Phosphatidylinositol 3-kinase Activator Activity
Regulation Of Protein Localization To Cell Periphery
Phosphatidylinositol 3-kinase Complex, Class IA
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
Regulation Of Cytoskeleton Organization
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Actin Cytoskeleton Organization
Insulin Receptor Substrate Binding
Leukocyte Mediated Cytotoxicity
Regulation Of D-glucose Transmembrane Transport
ERBB Signaling Pathway
Regulation Of Actin Filament-based Process
Signal Transduction
Signaling Adaptor Activity
Anchoring Junction
Actin Filament
Intracellular Glucose Homeostasis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Stress Fiber Assembly
Regulation Of Cell Communication
Regulation Of Signaling
Cytoskeleton Organization
Cellular Response To Insulin Stimulus
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Cell Motility
Cytoplasm
Cytosol
Regulation Of Cell Growth
Intracellular Signaling Cassette
Microtubule Binding
Regulation Of Growth
Microtubule Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Organelle Organization
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein-containing Complex
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cytoskeleton
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Kinase Activity
Positive Regulation Of Signaling
Regulation Of Signaling
Protein Metabolic Process
Regulation Of Developmental Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Myeloid Leukocyte Migration
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Cell Migration
Neutrophil Chemotaxis
Developmental Process
Cytoplasmic Microtubule
Microtubule-based Process
Ubiquitin Protein Ligase Binding
Catabolic Process
Leukocyte Migration
Protein Serine/threonine Kinase Activity
Protein Kinase Activity
Tubulin Binding
Negative Regulation Of Cell Growth
Cytoskeleton Organization
Neutrophil Migration
Protein Localization To Nucleus
Cellular Developmental Process
Microtubule Cytoskeleton
Microtubule
Positive Regulation Of Apoptotic Process
Leukocyte Aggregation
Regulation Of Microtubule-based Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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