SOCS7 and NSMF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SOCS7	NSMF
Description		suppressor of cytokine signaling 7	NMDA receptor synaptonuclear signaling and neuronal migration factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex	Euchromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Nuclear Matrix Dendrite Cortical Cytoskeleton Nuclear Membrane Cell Projection Neuron Projection Perikaryon Synapse Apical Dendrite
	Molecular Function	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration	Regulation Of Neuron Apoptotic Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Dendrite Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Electrical Stimulus Cellular Response To Gonadotropin Stimulus Regulation Of Neuron Migration Positive Regulation Of Neuron Migration
Pathways
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Ovarian cancer ( 23535730)
Interacting Genes		25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1	24 interacting genes: CALM1 CALM2 CALM3 CCDC125 CCNDBP1 GFI1B GOLGA2 GOLGA6L9 HSF2BP HSPB3 INTS11 KIFC3 LMO2 LXN MID2 MYL12B PNMA1 PTPN21 RAN SOCS7 TFIP11 TRIP6 UBASH3A VPS26C
Entrez ID		30837	26012
HPRD ID		12299	10485
Ensembl ID		ENSG00000274211	ENSG00000165802
Uniprot IDs		A0A5F9YLF9 O14512	A8K7L5 Q6X4W1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calyx Of Held Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Positive Regulation Of Sequestering Of Calcium Ion Sperm Midpiece Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Cytoplasm Sarcomere Spindle Pole Importin-alpha Family Protein Binding Neural Nucleus Development Adenylate Cyclase Binding Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Inhibitor Activity Voltage-gated Potassium Channel Complex Regulation Of Voltage-gated Calcium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
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