SOCS7 and GAS2L2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SOCS7	GAS2L2
Description		suppressor of cytokine signaling 7	growth arrest specific 2 like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex	Stress Fiber Cytoplasm Cytoskeleton Microtubule Actin Filament Plasma Membrane Membrane Microtubule Plus-end Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	G-protein Alpha-subunit Binding Protein Binding Microtubule Binding Cytoskeletal Anchor Activity Actin Filament Binding
	Biological Process	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration	Microtubule Bundle Formation Negative Regulation Of Microtubule Depolymerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Actin Crosslink Formation Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Microtubule Plus-end
Pathways
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1	33 interacting genes: ABI2 BANP C7orf57 CCNDBP1 DISC1 DNAAF6 EFHC1 GOLGA2 GOLGA6L9 HMBOX1 HOOK2 HSF2BP JADE2 KCTD7 LHX3 LNX1 LRP2BP MID2 MORN5 MTUS2 NAP1L1 PAX6 PICK1 PPP1R13B PRKAR1B RORB SAT1 SNW1 SOCS7 TFIP11 TRIM27 WWP2 ZRANB1
Entrez ID		30837	246176
HPRD ID		12299	11000
Ensembl ID		ENSG00000274211	ENSG00000270765
Uniprot IDs		A0A5F9YLF9 O14512	Q8NHY3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility	Cytoplasm Regulation Of Actin Nucleation Identical Protein Binding Positive Regulation Of Neural Precursor Cell Proliferation
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