CALM2 and CFTR

Number of citations of the paper that reports this interaction (PubMedID 35156780)
96

Data Source:
BioGRID (protein complementation assay)

		CALM2	CFTR
Description		calmodulin 2	CF transmembrane conductance regulator
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Spindle Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Sarcomere Synaptic Vesicle Membrane Vesicle Protein-containing Complex Calcium Channel Complex Myelin Sheath Calyx Of Held Sperm Midpiece Presynaptic Cytosol Catalytic Complex	Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Calcium Channel Inhibitor Activity Protein Kinase Binding Titin Binding Protein Serine/threonine Kinase Activator Activity Transmembrane Transporter Binding Metal Ion Binding Calcium-dependent Protein Binding Protein Phosphatase Activator Activity Transporter Inhibitor Activity	Nucleotide Binding Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein-folding Chaperone Binding 14-3-3 Protein Binding Sec61 Translocon Complex Binding ABC-type Transporter Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Substantia Nigra Development Regulation Of Cytokinesis Regulation Of Calcium-mediated Signaling Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Long-term Synaptic Potentiation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Endocytosis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Export Across Plasma Membrane	Cholesterol Biosynthetic Process Monoatomic Ion Transport Chloride Transport Water Transport Vesicle Docking Involved In Exocytosis Bicarbonate Transport Cholesterol Transport Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal-level Water Homeostasis Intracellular PH Elevation Establishment Of Localization In Cell Transmembrane Transport Membrane Hyperpolarization Regulation Of Biological Quality Positive Regulation Of Enamel Mineralization Cellular Response To CAMP Amelogenesis Inorganic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells
Drugs		Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate	ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases			Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens
GWAS		Dialysis-related mortality ( 21546767)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Type 1 diabetes ( 34012112) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		54 interacting genes: ADAMTS12 ADCY8 AKAP9 ASCL2 C11orf65 CACNA1A CALD1 CAMTA2 CCND2 CFTR DDIT4L DLG1 DRC9 EDF1 EGFR ESR1 ESR2 GRM5 GRM7 GSC2 INSR INVS IQCB1 IQCE IQCN IQGAP3 IQSEC2 KCNIP3 KCNN1 KCNQ2 KCNQ3 KCNQ5 MARCKS MRPL20 MYF5 MYF6 MYO6 MYOD1 MYOG NEUROD1 NSMF PCNT POC5 PPEF1 PPEF2 RAB3B RPSA SDCBP SPATA17 STK11 TBC1D1 TCF4 USP6 ZNF280A	466 interacting genes: A4GALT AARSD1 ABCC11 ABRAXAS1 ACCS ACOT8 ACRV1 ADAMTS1 ADAT1 ADCYAP1 ADRB3 AFMID AGBL4 AGO3 AHCYL1 AK8 AKR7A3 ALDOC ALKBH7 ANKRD49 ANKS3 ANTXR2 AP5B1 APOC2 AQP4-AS1 ARFGAP3 ARHGAP8 ARHGEF9 ARMC9 ASIC4 ASPDH ATOSB BACH1 BCAS1 BDH2 BEND5 BHLHA15 BICDL2 C19orf38 C1orf162 C7 C8orf33 C9orf43 CAB39L CABCOCO1 CALHM5 CALM2 CAMKK1 CAMKV CANX CAP1 CAPZB CASP1 CASQ2 CBR4 CCDC110 CCDC146 CCDC167 CCDC197 CCDC66 CCDC9 CCNYL6 CD22 CD68 CEP55 CFHR5 CGB2 CGB3 CGB5 CGB8 CGREF1 CHCHD10 CHMP2B CHRFAM7A CHRM4 CHRNA7 CHST14 CHST5 CIMIP5 CLCN3 CLCNKB CLEC10A CLEC12A CLEC7A CLIC1 COASY COL21A1 COL23A1 COL9A1 COPG1 COX18 CRABP1 CRACR2B CREB3L1 CSHL1 CSNK1G2-AS1 CUL1 CUTC CWC22 CYB561D1 CYP4F12 DACH2 DARS2 DAZ3 DAZ4 DDRGK1 DDX19A DDX20 DEF8 DEFB119 DEGS1 DERL1 DHX30 DLX6 DNAJA1 DNAJB14 DNAJC1 DNAJC5 DOCK10 DPF3 DPP7 DPPA3 DQX1 DRG1 DSTN DUSP7 EDF1 EEIG1 EFCAB11 EGLN3 EIF4E3 EMG1 ENPP5 EPHX1 EPO ERCC6L EREG ERICH5 ERMAP ETFA EVL EZR FAAP100 FABP2 FAM153CP FAM222A FAM9C FANCB FASTKD2 FBXO11 FCGR3A FCHO1 FGD5 FGL2 FHL2 FKBP6 FKBP6P2 FKBP7 FMOD FNIP1 FNTA GABRG2 GADD45B GAREM1 GCKR GCLM GDAP2 GFOD3P GGA1 GIMAP4 GINM1 GINS3 GNAS GNAZ GNB2 GOPC GPX1 GSDME GSTO1 GSTT2 GSTT2B GTF2F1 H2BC7 HACL1 HAND2-AS1 HAUS4 HDDC3 HEYL HHIPL2 HINT2 HK1 HMMR HNMT HOMER3 HSD17B2 HSP90AA1 HSPA14 HSPD1 HTATIP2 HTR5A IGKC IGKV1-5 IGKV2-24 IGLV4-3 IKZF2 IL12RB1 IL13 IL36A INHBA INIP INTU IQUB ISOC1 ITM2C JADE1 KATNAL1 KIF12 KLHDC7B KLHL18 KLK14 KPNA5 KRT13 KRT31 KRTAP26-1 LCMT1 LGALS14 LGALS2 LGALS9 LIAS LINC03042 LLCFC1 LMBR1L LMX1B LPCAT4 LRFN4 LRRC37B LRRC57 LSP1 LUM LURAP1L MAGEB2 MAGEC3 MAN1A1 MAP3K19 MARCHF2 MC3R MCCC2 MCPH1 MED11 MEIOB MELTF METTL14 METTL2A MGAT5B MGP MIER2 MORN3 MOS MPI MREG MRPS27 MSH4 MTFR2 MTMR14 MTRES1 MYADM MYEOV MYLK2 MYOG NAA10 NCCRP1 NEU4 NFAM1 NFIL3 NHERF1 NHERF2 NHERF4 NHLH2 NHS NIT2 NOD1 NOP53 NRIP3 NUDT1 OLFM4 OPTN OR5M8 OR7E91P OSTM1 OTC OTUD6A P2RY6 PBDC1 PBX3 PBX4 PCP4L1 PDHA1 PDIA3 PDS5B PDZK1 PGAP2 PIK3R5 PISD PLEKHB2 PNMA1 PNP POGLUT3 POLE POLR1F POU5F1 PPP1R21 PPP2R1B PRAF2 PRDM1 PRDM4 PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 PROKR1 PRSS45P PSMD4 PTCD1 PTTG1 PVRIG PWP2 PYROXD1 RASL10B RBM14 RDH12 RDH13 RFFL RFWD3 RGS13 RND3 RNF139 RNF5 RPS6KB2 RRS1 SAMD3 SAMD4B SAXO4 SCAMP1 SCN2B SDHA SDR9C7 SEC22C SEMA3E SERAC1 SERPINA3 SERPINA4 SERPINB10 SERPIND1 SERPING1 SH3BP4 SHC1 SLC10A1 SLC10A6 SLC14A1 SLC25A51P4 SLC26A11 SLC33A1 SLC35B4 SLC38A7 SLC44A5 SLC4A7 SLC4A8 SLC66A1LP SLC7A10 SLC9A6 SLC9B1 SMARCD1 SMIM21 SMYD1 SMYD3 SNAP23 SNRPN SORBS3 SOX15 SPATA6L SPEF1 SPSB3 SRP68 ST6GALNAC1 STAP2 STAU1 STIMATE STK26 STRADA STUB1 STX1A SYNE4 SYT12 TAFA3 TAFAZZIN TASL TBP TCTN3 TFEB TFF2 TFG TFR2 TGFB1 TGS1 THAP11 TIMD4 TK1 TLCD4 TLR3 TMEM237 TMEM277P TMEM40 TMPRSS6 TNFSF10 TONSL TOR1B TRAFD1 TRIM16 TRIM16L TRIM27 TRIM32 TRIM5 TRMT1 TSC22D1 TTR TXNRD2 UBE2I ULK3 UNC119 UNC45B UNC93B1 USP10 USP26 USP28 VAMP4 VAPA VAPB VASN VAV1 VDAC2 VEGFA VEPH1 VPS28 VPS4A VPS4B VTI1B WDR5B WWP2 XAGE3 XKR8 YTHDF1 ZBED2 ZC2HC1B ZDHHC15 ZFP57 ZFYVE26 ZGRF1 ZNF112 ZNF213 ZNF22 ZNF462 ZNF69 ZNF770 ZUP1
Entrez ID		805	1080
HPRD ID		00242	03883
Ensembl ID		ENSG00000143933	ENSG00000001626
Uniprot IDs		P0DP23 P0DP24 P0DP25 Q96HY3	P13569
PDB IDs		1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EVV 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6HR1 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6K67 6M2W 6M7H 6MUD 6MUE 6N5W 6O5G 6OS4 6PAW 6PBX 6PBY 6PLM 6S5T 6SZ5 6TV7 6U39 6U3A 6U3B 6U3D 6UZZ 6V00 6V01 6X32 6X33 6X35 6X36 6XXF 6XXX 6XY3 6XYR 6Y4O 6Y4P 6Y94 6Y95 6YA9 6YNS 6YNU 6ZBI 7AUG 7BF1 7BF2 7BYL 7BYM 7BYN 7CR3 7CR4 7CR7 7KL5 7L8V 7MIR 7MIS 7PPO 7PQE 7PSZ 7PU9 7SHQ 7SX3 7SX4 7T2Q 7TCI 7TCP 7TZC 7U9T 7UA3 7UA4 7VMB 7VNP 7VNQ 7VNR 7VUO 7VUR 7VUS 7VUT 7VUU 7VVD 7VVH 7WJI 7WR3 7WR4 7WR5 7WZS 7XN4 7XN5 7XN6 7XNI 7XNK 7XNL 7XNN 7ZRP 7ZRQ 8AHS 8B6Q 8BD2 8BFG 8DGH 8DGK 8DUJ 8DVE 8EOW 8EP0 8EP1 8FNY 8FO6 8GM4 8GM5 8IJK 8J00 8J01 8J02 8J03 8J04 8J05 8J07 8JFK 8K9Z 8KA0 8KA1 8ODZ 8OE0 8OE4 8PB1 8SIK 8SIM 8SIN 8UXL 8UXM 8W4U 8X43 8XJI 8XKH 8XLF 8XLH 8XO1 8XYA 8XYB 8Y40 9CUI 9CUK 9E17 9JQI 9K8W 9K8X	1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1 6WBS 6ZE1 7QI1 7SV7 7SVD 7SVR 8EIG 8EIO 8EIQ 8EJ1 8FZQ 8GLS 8UBR 8V7Z 8V81 9DW4 9DW5 9DW7 9DW8 9DW9
Enriched GO Terms of Interacting Partners?		Calmodulin Binding E-box Binding Protein Dimerization Activity Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Cellular Response To Estradiol Stimulus Muscle Cell Fate Commitment Voltage-gated Potassium Channel Complex Positive Regulation Of Skeletal Muscle Tissue Development Chemical Synaptic Transmission Positive Regulation Of Striated Muscle Tissue Development Trans-synaptic Signaling Regulation Of Skeletal Muscle Tissue Development Synaptic Signaling Regulation Of Developmental Process Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Sequence-specific DNA Binding Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Cellular Response To Oxygen-containing Compound Cell-cell Signaling Signaling Node Of Ranvier Response To Estradiol Cell Communication Skeletal Muscle Cell Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Monoatomic Ion Channel Complex Positive Regulation Of Developmental Process Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skeletal Muscle Tissue Development Cilium Positive Regulation Of Muscle Cell Differentiation Cellular Response To Lipid Regulation Of Myoblast Differentiation Potassium Channel Activity Chromatin Potassium Ion Transmembrane Transport Muscle Tissue Development Positive Regulation Of Long-term Synaptic Depression Cytoplasm Membrane Hyperpolarization Potassium Ion Transport Regulation Of Striated Muscle Cell Differentiation DNA-binding Transcription Factor Activity Response To Electrical Stimulus
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