DLAT and PDK1

Number of citations of the paper that reports this interaction (PubMedID 29568061)
70

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		DLAT	PDK1
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Pyruvate Catabolic Process	Glucose Metabolic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Cellular Response To Stress Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Protein lipoylation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation
Drugs		NADH Radicicol Dihydrolipoic Acid	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		10 interacting genes: FOXP1 HMGB1 HUNK PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	16 interacting genes: AKT1 BIN1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ
Entrez ID		1737	5163
HPRD ID		10578	03954
Ensembl ID		ENSG00000150768	ENSG00000152256
Uniprot IDs		A0A7P0T997 A0A7P0TAG1 A0A7P0TAX2 A0A7P0TBE2 A0A7P0TBK2 E9PEJ4 H0YDD4 P10515 Q86YI5	B7Z207 B7Z7N6 Q15118
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55 8PIU	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Glucose Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Protein Kinase Activity Regulation Of Fatty Acid Metabolic Process Kinase Activity Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Glucose Metabolic Process ATP Binding Carbohydrate Metabolic Process Cellular Response To Stress Mitochondrion Hexose Metabolic Process Acetyl-CoA Metabolic Process Monosaccharide Metabolic Process Nucleotide Binding Transferase Activity T-helper Cell Differentiation Regulation Of Phosphorus Metabolic Process Cellular Response To Fatty Acid T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation Response To Fatty Acid Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Macrophage Activation Regulation Of Interleukin-12 Production Alpha-beta T Cell Differentiation Pyruvate Metabolic Process T Cell Activation Involved In Immune Response Response To Lipid Insulin Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Interleukin-21 Production Acyl-CoA Metabolic Process	Glucose Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Positive Regulation Of TOR Signaling Insulin Receptor Signaling Pathway Pyruvate Dehydrogenase Complex Carbohydrate Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus TOR Signaling Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of TORC1 Signaling Cellular Response To Insulin Stimulus Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Programmed Cell Death Tricarboxylic Acid Cycle Cellular Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Protein-containing Complex Cellular Response To Nutrient Response To Peptide Hormone Cellular Response To Oxygen-containing Compound Transferase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Translational Initiation Response To Hormone Phosphate-containing Compound Metabolic Process Response To Insulin Kinase Activity Pyruvate Decarboxylation To Acetyl-CoA ATP Binding Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction Pyruvate Metabolic Process Regulation Of Biological Quality Organic Acid Metabolic Process Response To Ketone Anoikis Positive Regulation Of Intracellular Signal Transduction Response To Activity Positive Regulation Of Signal Transduction
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