DLAT and PDK2

Number of citations of the paper that reports this interaction (PubMedID 11978179)
33

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		DLAT	PDK2
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Pyruvate Catabolic Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Stress Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Protein lipoylation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH Radicicol Dihydrolipoic Acid	4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: FOXP1 HMGB1 HUNK PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		1737	5164
HPRD ID		10578	03955
Ensembl ID		ENSG00000150768	ENSG00000005882
Uniprot IDs		A0A7P0T997 A0A7P0TAG1 A0A7P0TAX2 A0A7P0TBE2 A0A7P0TBK2 E9PEJ4 H0YDD4 P10515 Q86YI5	Q15119
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55 8PIU	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2 7EA0 7EAS 7EBH 7VBU 7VBV 7VBX 8ZM1 8ZM2
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Glucose Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Protein Kinase Activity Regulation Of Fatty Acid Metabolic Process Kinase Activity Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Glucose Metabolic Process ATP Binding Carbohydrate Metabolic Process Cellular Response To Stress Mitochondrion Hexose Metabolic Process Acetyl-CoA Metabolic Process Monosaccharide Metabolic Process Nucleotide Binding Transferase Activity T-helper Cell Differentiation Regulation Of Phosphorus Metabolic Process Cellular Response To Fatty Acid T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation Response To Fatty Acid Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Macrophage Activation Regulation Of Interleukin-12 Production Alpha-beta T Cell Differentiation Pyruvate Metabolic Process T Cell Activation Involved In Immune Response Response To Lipid Insulin Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Interleukin-21 Production Acyl-CoA Metabolic Process	Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Acetyl-CoA Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Pyruvate Metabolic Process Mitochondrion Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Carbohydrate Metabolic Process Phosphate-containing Compound Metabolic Process Mitochondrial Matrix Amide Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Tricarboxylic Acid Cycle Positive Regulation Of Cilium Assembly Protein Kinase Activity Positive Regulation Of Transporter Activity Purine-containing Compound Biosynthetic Process T Cell Costimulation Kinase Activity Sulfur Compound Metabolic Process Regulation Of TRNA Methylation Protein Destabilization Nucleoside Phosphate Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly Regulation Of T Cell Activation Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity Mammalian Oogenesis Stage Protein Phosphorylation Regulation Of Glucose Metabolic Process Kinase Binding TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Small Molecule Metabolic Process Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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