DLAT and PRKD3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DLAT	PRKD3
Gene Name		dihydrolipoamide S-acetyltransferase	protein kinase D3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex	Nucleoplasm Cytoplasm Membrane
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding	Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Protein Phosphorylation Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH Radicicol Dihydrolipoic Acid
Diseases
GWAS
Protein-Protein Interactions		8 interactors: PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	9 interactors: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 NUDT3 SKA2 VAMP2
Entrez ID		1737	23683
HPRD ID		10578	06151
Ensembl ID		ENSG00000150768	ENSG00000115825
Uniprot IDs		P10515 Q86YI5	O94806
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL	2D9Z
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Acetyl-CoA Biosynthetic Process Insulin Receptor Signaling Pathway Acetyl-CoA Metabolic Process Protein Phosphorylation Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphorylation Tricarboxylic Acid Metabolic Process Aerobic Respiration Acyl-CoA Metabolic Process Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hormone Stimulus Cellular Response To Stress Phosphate-containing Compound Metabolic Process Coenzyme Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration	Protein Import Into Nucleus Nuclear Import Protein Import NLS-bearing Protein Import Into Nucleus Protein Localization To Nucleus Protein Import Into Nucleus, Translocation Cytoplasmic Transport Nucleocytoplasmic Transport Nuclear Transport Energy Derivation By Oxidation Of Organic Compounds Intracellular Protein Transport Establishment Of Protein Localization To Organelle Regulation Of DNA Recombination Negative Regulation Of UDP-glucose Catabolic Process Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Establishment Of Localization In Cell Negative Regulation Of Intracellular Signal Transduction Generation Of Precursor Metabolites And Energy Protein Targeting Protein Localization To Organelle Negative Regulation Of Type B Pancreatic Cell Development Immune Response Viral Process Cellular Localization Signaling Cellular Protein Localization Cell Communication Cellular Response To Cytokine Stimulus Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Eosinophil Degranulation Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Isotype Switching To IgE Isotypes Energy Reserve Metabolic Process Protein Transport Establishment Of Protein Localization Hypermethylation Of CpG Island Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Cell Growth Intracellular Transport Positive Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Interleukin-3 Response To Cytokine Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Establishment Of Vesicle Localization
Tagcloud ?		accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Difference) ?		accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates	advantageous characterize chimpanzee crebbp eleven ep300 evolution fgf2 germ gorilla hdac3 macaque macaques mapped microarrays orangutan organs partners primate profiled profiling proteomics regard runx1 runx2 satb2 tcf3 testis yap1
Tagcloud (Intersection) ?