DLAT and PDK3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DLAT	PDK3
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleolus Mitochondrion Mitochondrial Matrix
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Pyruvate Catabolic Process	Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Cellular Response To Stress Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Protein lipoylation PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH Radicicol Dihydrolipoic Acid	Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Malaria ( 31844061)
Interacting Genes		10 interacting genes: FOXP1 HMGB1 HUNK PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	4 interacting genes: APP DLAT EGFR PDHA1
Entrez ID		1737	5165
HPRD ID		10578	03956
Ensembl ID		ENSG00000150768	ENSG00000067992
Uniprot IDs		A0A7P0T997 A0A7P0TAG1 A0A7P0TAX2 A0A7P0TBE2 A0A7P0TBK2 E9PEJ4 H0YDD4 P10515 Q86YI5	Q15120
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55 8PIU	1Y8N 1Y8O 1Y8P 2PNR 2Q8I
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Glucose Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Protein Kinase Activity Regulation Of Fatty Acid Metabolic Process Kinase Activity Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Glucose Metabolic Process ATP Binding Carbohydrate Metabolic Process Cellular Response To Stress Mitochondrion Hexose Metabolic Process Acetyl-CoA Metabolic Process Monosaccharide Metabolic Process Nucleotide Binding Transferase Activity T-helper Cell Differentiation Regulation Of Phosphorus Metabolic Process Cellular Response To Fatty Acid T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation Response To Fatty Acid Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Macrophage Activation Regulation Of Interleukin-12 Production Alpha-beta T Cell Differentiation Pyruvate Metabolic Process T Cell Activation Involved In Immune Response Response To Lipid Insulin Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Interleukin-21 Production Acyl-CoA Metabolic Process	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Acetyl-CoA Metabolic Process Tricarboxylic Acid Cycle Pyruvate Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Sulfur Compound Biosynthetic Process Acyl-CoA Metabolic Process Multivesicular Body, Internal Vesicle Lumen Glucose Metabolic Process Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Dihydrolipoyllysine-residue Acetyltransferase Activity Monosaccharide Metabolic Process Amide Biosynthetic Process Hexose Metabolic Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Pyruvate Dehydrogenase (acetyl-transferring) Activity Receptor Complex Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Early Endosome Membrane Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle
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