DLAT and PDK4

Number of citations of the paper that reports this interaction (PMID 11978179)
14

Data Source:
HPRD (in vitro)

		DLAT	PDK4
Gene Name		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase, isozyme 4
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Cellular Metabolic Process Small Molecule Metabolic Process Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		NADH Radicicol Dihydrolipoic Acid
Diseases
GWAS
Protein-Protein Interactions		8 interactors: PDHA1 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	3 interactors: DLAT PDHA1 TRIM63
Entrez ID		1737	5166
HPRD ID		10578	03957
Ensembl ID		ENSG00000150768	ENSG00000004799
Uniprot IDs		P10515 Q86YI5	A4D1H4 Q16654
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL	2E0A 2ZDX 2ZDY 2ZKJ 3D2R
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Acetyl-CoA Biosynthetic Process Insulin Receptor Signaling Pathway Acetyl-CoA Metabolic Process Protein Phosphorylation Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphorylation Tricarboxylic Acid Metabolic Process Aerobic Respiration Acyl-CoA Metabolic Process Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hormone Stimulus Cellular Response To Stress Phosphate-containing Compound Metabolic Process Coenzyme Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Cellular Respiration Hexose Metabolic Process Monosaccharide Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Skeletal Muscle Atrophy Striated Muscle Atrophy Acetyl-CoA Biosynthetic Process Muscle Atrophy Generation Of Precursor Metabolites And Energy Skeletal Muscle Adaptation Regulation Of Cellular Ketone Metabolic Process Monocarboxylic Acid Metabolic Process Acetyl-CoA Metabolic Process Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Carboxylic Acid Metabolic Process Response To Electrical Stimulus Carbohydrate Metabolic Process Cellular Response To Glucocorticoid Stimulus Organic Acid Metabolic Process Cellular Response To Corticosteroid Stimulus Acyl-CoA Metabolic Process Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Oxidation-reduction Process Glycolytic Process Catabolic Process Coenzyme Biosynthetic Process Carbohydrate Catabolic Process Response To Glucocorticoid Response To Corticosteroid Cellular Response To Steroid Hormone Stimulus
Tagcloud ?		accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates	bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic
Tagcloud (Difference) ?		accumulate acyltransferase adapts bckadh branched dehydrogenase dihydrolipoamide helps immunodeficient infectives intermediates keto lipoamide lpd lpdc metabolize nutritionally pdh pdha pdhb pdhc peroxidase peroxynitrite persist phenocopies pnr pyruvate resist upregulates	bioinformatic desaturation diabesity discriminant dock1 elutriated ether fam126a gnptab goes granulocytes klf4 lipidome lipidomic monocyte mufa nfy pe peroxisomal phagocytic plasmalogen plasmalogens pls pufa rhm rnf96 silico squares transcriptomic
Tagcloud (Intersection) ?