HTT and HAP1

Number of citations of the paper that reports this interaction (PubMedID 9454836)
49

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HTT	HAP1
Description		huntingtin	huntingtin associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol	Nucleus Nucleolus Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Neuron Projection Dendritic Spine Synapse Presynapse Axon Cytoplasm
	Molecular Function	P53 Binding Phosphoprotein Phosphatase Activity Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Transmembrane Transporter Binding Dynein Intermediate Chain Binding Beta-tubulin Binding	Signaling Receptor Binding Protein Binding Myosin Binding Transmembrane Transporter Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Microtubule-based Process Golgi Organization Central Nervous System Development Regulation Of Signal Transduction Neurogenesis Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Synaptic Vesicle Transport Positive Regulation Of Mitophagy Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Intracellular Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways		Regulation of MECP2 expression and activity
Drugs		Copper
Diseases		Huntington's disease (HD)
GWAS		Age at first birth ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Frailty index ( 34431594) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Walking pace ( 33128006) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		111 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 PSME4 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655	93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C7orf25 C8orf33 CATSPERT CBX8 CCDC13 CDC73 CDK18 CDK5RAP2 CFAP263 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835
Entrez ID		3064	9001
HPRD ID		00883	02972
Ensembl ID		ENSG00000197386	ENSG00000173805
Uniprot IDs		P42858	P54257
PDB IDs		2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O 6YEJ 7DXJ 7DXK 8R2O 8SAH 8VLX 8W15
Enriched GO Terms of Interacting Partners?		Protein Binding Cellular Response To Stress Nucleoplasm Nucleus Identical Protein Binding Positive Regulation Of Cellular Component Biogenesis Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Cellular Component Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Positive Regulation Of Organelle Organization Interleukin-18-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-translational Protein Modification Transcription Coregulator Activity Regulation Of Cellular Response To Stress Protein-containing Complex Positive Regulation Of Metabolic Process	Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole DNA Replication-dependent Chromatin Disassembly Establishment Of Spindle Orientation Regulation Of Microtubule Nucleation Chromatin Organization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Metabolic Process Establishment Of Spindle Localization Positive Regulation Of Aggrephagy Protein Import Into Mitochondrial Matrix RNA Polymerase Transcription Factor SL1 Complex Histone Acetyltransferase Complex Spindle Localization Regulation Of Microtubule Polymerization Regulation Of Macromolecule Metabolic Process Establishment Of Organelle Localization Centriolar Satellite Male Pronucleus Troponin Complex Protein Acetylation Histone H4K16 Acetyltransferase Activity Gamma-tubulin Binding
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