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HTT and PIK3R1
Number of citations of the paper that reports this interaction (PubMedID
23275563
)
50
Data Source:
BioGRID
(two hybrid)
HTT
PIK3R1
Description
huntingtin
phosphoinositide-3-kinase regulatory subunit 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Golgi Apparatus
Centriole
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Protein-containing Complex
Synapse
Perinuclear Region Of Cytoplasm
Presynaptic Cytosol
Postsynaptic Cytosol
Nucleus
Cytoplasm
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell-cell Junction
Phosphatidylinositol 3-kinase Complex
Phosphatidylinositol 3-kinase Complex, Class IA
Membrane
Perinuclear Region Of Cytoplasm
Perinuclear Endoplasmic Reticulum Membrane
Molecular Function
P53 Binding
Phosphoprotein Phosphatase Activity
Protein Binding
Profilin Binding
Kinase Binding
Heat Shock Protein Binding
Dynactin Binding
Identical Protein Binding
Transmembrane Transporter Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
GTPase Activator Activity
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Kinase Regulator Activity
Kinase Activator Activity
Protein Phosphatase Binding
Phosphatidylinositol 3-kinase Regulator Activity
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
ErbB-3 Class Receptor Binding
Phosphatidylinositol 3-kinase Binding
Insulin Binding
Insulin Receptor Substrate Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Phosphatidylinositol Kinase Activity
Enzyme-substrate Adaptor Activity
Phosphatidylinositol 3-kinase Activator Activity
Biological Process
Establishment Of Mitotic Spindle Orientation
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Apoptotic Process
Microtubule-based Process
Golgi Organization
Central Nervous System Development
Regulation Of Signal Transduction
Neurogenesis
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Destabilization
Vocal Learning
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cilium Assembly
Vesicle Transport Along Microtubule
Synaptic Vesicle Transport
Positive Regulation Of Mitophagy
Positive Regulation Of Lipophagy
Regulation Of CAMKK-AMPK Signaling Cascade
Positive Regulation Of CAMKK-AMPK Signaling Cascade
Positive Regulation Of Aggrephagy
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Intracellular Glucose Homeostasis
Negative Regulation Of Cell-matrix Adhesion
Positive Regulation Of Leukocyte Migration
Transcription By RNA Polymerase II
Protein Import Into Nucleus
Immune Response
Negative Regulation Of Cell Adhesion
Signal Transduction
Insulin Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Lamellipodium Assembly
Protein Transport
Cytokine-mediated Signaling Pathway
B Cell Differentiation
T Cell Differentiation
Osteoclast Differentiation
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Positive Regulation Of RNA Splicing
Regulation Of Toll-like Receptor 4 Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
Interleukin-18-mediated Signaling Pathway
Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Osteoclast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of D-glucose Import
Phosphatidylinositol Phosphate Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
T Follicular Helper Cell Differentiation
Myeloid Leukocyte Migration
Positive Regulation Of Focal Adhesion Disassembly
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization To Plasma Membrane
Pathways
Regulation of MECP2 expression and activity
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PI3K events in ERBB4 signaling
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
GAB1 signalosome
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
PI3K events in ERBB2 signaling
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
GP1b-IX-V activation signalling
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Activated NTRK3 signals through PI3K
FLT3 Signaling
FLT3 Signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF1 (M-CSF) in myeloid cells
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by FLT3 fusion proteins
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by ALK fusions and activated point mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK in cancer
Signaling by LTK
Co-stimulation by ICOS
Drugs
Copper
SF1126
Enzastaurin
Wortmannin
Diseases
Huntington's disease (HD)
GWAS
Age at first birth (
34211149
)
Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) (
32678081
)
Alcohol consumption (
31358974
)
Estimated glomerular filtration rate (
31152163
)
Frailty index (
34431594
)
Hip circumference adjusted for BMI (
34021172
)
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean platelet volume (
32888494
)
Monobrow (
27182965
)
Myocardial infarction (
33532862
)
Neutrophil count (
32888494
)
Parental lifespan (
30642433
)
Platelet count (
32888494
)
Serum sulfate level (
27412988
)
Tuberculosis (
29036319
)
Type 2 diabetes (
30297969
)
Walking pace (
33128006
)
White blood cell count (
32888494
)
Worry too long after an embarrassing experience (
29500382
)
Worry/vulnerability (special factor of neuroticism) (
30867560
)
Alzheimer's disease biomarkers (
23419831
)
Anthropometric traits (multi-trait analysis) (
30166351
)
Appendicular lean mass (
33097823
)
Basal cell carcinoma (
33549134
)
Birth weight (
31043758
)
Body fat percentage and HDL-C (pairwise) (
33619380
)
Bone mineral density (hip) (
26911590
)
Corneal astigmatism (
30306274
)
Crohn's disease (
32581322
)
Estimated glomerular filtration rate (
30604766
31152163
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
HDL cholesterol levels (
32203549
)
Height (
31562340
)
Hip minimal joint space width (
27701424
)
Intelligence (MTAG) (
29326435
)
Leg fat mass (lean adjusted) (
32719433
)
Leg fat mass and leg lean mass (pleiotropy) (
32719433
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Menarche (age at onset) (
23599027
)
Offspring birth weight (
31043758
)
Red cell distribution width (
32888494
27863252
)
Rosacea symptom severity (
29771307
)
Triglyceride levels (
32203549
29083408
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
111 interacting genes:
AKT1
AMFR
AP2A2
BDKRB1
CASP1
CASP3
CASP6
CBS
CEP126
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ELP1
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
H2AP
H3C10
HAP1
HEYL
HIP1
HIP1R
HOXC11
HOXC4
HSP90AA1
HSPA8
HYPK
IFT20
IKBKB
ING5
KAT2B
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUP58
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
PSME4
RASA1
REST
RHEB
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
180 interacting genes:
ABL1
ADAM12
ADAMTS2
AGAP2
AKT1
ALK
ANK3
APPL1
AR
ARAF
ARHGAP1
ARHGAP17
ARHGAP32
AXL
BCAR1
BLK
BRCA1
CBL
CBLB
CCL14
CD19
CD22
CD28
CD2AP
CD3E
CD4
CD40
CD5
CD7
CDC42
CDH2
CHRNA7
CIP2A
CLNK
CRK
CRKL
CSF1R
CSF2RA
CTLA4
CTNNB1
CXCL2
CYP4A11
DLX2
DNM1
DOK1
EGF
EGFR
ENKUR
EPHA2
EPOR
ERAS
ERBB2
ERBB3
ERBB4
ESR1
EZR
FASLG
FBXO21
FCGR2A
FER
FES
FGFR1
FLT1
FYN
GAB1
GAB2
GAB3
GHR
GP1BA
GRB2
GSPT1
GTF2H1
HCK
HCST
HGS
HOXA1
HRAS
HTT
IFNAR1
IGF1R
IKZF3
IL13
IL1R1
IL1RAP
IL2RB
IL7R
INPP4A
INSR
IRS1
IRS2
IRS4
ITSN1
JAK1
JAK2
JAK3
KBTBD2
KHDRBS1
KIT
LAT
LCK
LNX2
LRRK2
MAPK8
MAPT
MET
MME
MST1R
MYO16
NFKBIA
NLRP6
NTRK1
NTRK2
NUP85
NYAP1
NYAP2
PASK
PDE4D
PDGFB
PDGFRA
PDGFRB
PECAM1
PFN1
PIK3AP1
PIK3CA
PIK3CB
PIK3CD
PPM1A
PRMT8
PROM1
PSEN1
PSMB5
PTEN
PTK2
PTK2B
PTPN11
PTPN6
RAC1
RASA1
RASD2
RB1
RET
RRAS2
SH3KBP1
SHB
SHC1
SLC9A2
SOCS1
SOCS6
SOCS7
SQSTM1
SRC
SSTR2
STAT3
SYK
SYN1
TEC
TEK
TGFBR1
TGFBR2
TIE1
TLR2
TNK2
TNS4
TOM1L1
TRAT1
TRIM25
TSHR
TTR
TUB
TUBA1B
TUBG1
TXK
TYK2
TYRO3
VAV1
VAV3
WAS
WASF3
WBP11
YWHAG
Entrez ID
3064
5295
HPRD ID
00883
01381
Ensembl ID
ENSG00000197386
ENSG00000145675
Uniprot IDs
P42858
A0A2X0SFG1
P27986
PDB IDs
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
4RAV
6EZ8
6N8C
6RMH
6X9O
6YEJ
7DXJ
7DXK
8R2O
8SAH
8VLX
8W15
1A0N
1AZG
1H9O
1PBW
1PHT
1PIC
1PKS
1PKT
2IUG
2IUH
2IUI
2RD0
2V1Y
3HHM
3HIZ
3I5R
3I5S
4A55
4JPS
4L1B
4L23
4L2Y
4OVU
4OVV
4WAF
4YKN
4ZOP
5AUL
5FI4
5GJI
5ITD
5M6U
5SW8
5SWG
5SWO
5SWP
5SWR
5SWT
5SX8
5SX9
5SXA
5SXB
5SXC
5SXD
5SXE
5SXF
5SXI
5SXJ
5SXK
5UBT
5UK8
5UKJ
5UL1
5VLR
5XGH
5XGI
5XGJ
6NCT
6PYR
6PYU
7CIO
7LM2
7LQ1
7MYN
7MYO
7PG5
7PG6
7RNS
7TZ7
8AM0
8DCP
8DCX
8DD4
8DD8
8GUB
8H36
8H37
8ILR
8ILS
8ILV
8SBC
8SBJ
8TDU
8TGD
8TS7
8TS8
8TS9
8TSA
8TSB
8TSC
8TSD
8TU6
8V8H
8V8I
8V8J
8V8U
8V8V
8W9A
8W9B
Enriched GO Terms of Interacting Partners
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Protein Binding
Cellular Response To Stress
Nucleoplasm
Nucleus
Identical Protein Binding
Positive Regulation Of Cellular Component Biogenesis
Cytoplasm
Ubiquitin Protein Ligase Binding
Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Metabolic Process
Positive Regulation Of Cellular Component Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Cytosol
Regulation Of Cellular Component Organization
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Innate Immune Response
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Negative Regulation Of Macromolecule Metabolic Process
Protein Stabilization
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Corepressor Activity
Positive Regulation Of Organelle Organization
Interleukin-18-mediated Signaling Pathway
Regulation Of Defense Response
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Post-translational Protein Modification
Transcription Coregulator Activity
Regulation Of Cellular Response To Stress
Protein-containing Complex
Positive Regulation Of Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Signal Transduction
Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Plasma Membrane
Regulation Of Signal Transduction
Regulation Of Cell Communication
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune System Process
Protein Kinase Activity
Regulation Of Immune Response
Kinase Activity
Positive Regulation Of Multicellular Organismal Process
Transmembrane Receptor Protein Tyrosine Kinase Activity
Immune Response-activating Cell Surface Receptor Signaling Pathway
Phosphorylation
Immune Response-regulating Signaling Pathway
Regulation Of MAPK Cascade
Positive Regulation Of Cell Population Proliferation
Protein Phosphorylation
Receptor Complex
Positive Regulation Of MAPK Cascade
Intracellular Signaling Cassette
Regulation Of Cell Population Proliferation
Regulation Of Cell Activation
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune Response
Cell Migration
Cytokine-mediated Signaling Pathway
Protein Autophosphorylation
Regulation Of Developmental Process
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Migration
Activation Of Immune Response
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Tagcloud (Difference)
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Tagcloud (Intersection)
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