HTT and TPR

Number of citations of the paper that reports this interaction (PubMedID 15654337)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HTT	TPR
Description		huntingtin	translocated promoter region, nuclear basket protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Cytoplasmic Dynein Complex Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle
	Molecular Function	P53 Binding Phosphoprotein Phosphatase Activity Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Transmembrane Transporter Binding Dynein Intermediate Chain Binding Beta-tubulin Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Tubulin Binding Structural Constituent Of Nuclear Pore Heat Shock Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Mitogen-activated Protein Kinase Binding Dynein Complex Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Microtubule-based Process Golgi Organization Central Nervous System Development Regulation Of Signal Transduction Neurogenesis Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Synaptic Vesicle Transport Positive Regulation Of Mitophagy Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II RNA Import Into Nucleus RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Nuclear Pore Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of MRNA Export From Nucleus Regulation Of Mitotic Sister Chromatid Separation Protein Transport Positive Regulation Of Heterochromatin Formation Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Regulation Of Protein Localization Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Negative Regulation Of Translational Initiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Nuclear Pore Complex Assembly Cell Division Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly
Pathways		Regulation of MECP2 expression and activity	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants
Drugs		Copper
Diseases		Huntington's disease (HD)	Thyroid cancer
GWAS		Age at first birth ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Frailty index ( 34431594) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Walking pace ( 33128006) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		111 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 PSME4 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655	19 interacting genes: APC CDK1 ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 MECOM NUP153 NUP98 PRKACA SHC1 SUMO2 USP7 WEE2-AS1 YWHAQ ZC3HC1
Entrez ID		3064	7175
HPRD ID		00883	08927
Ensembl ID		ENSG00000197386	ENSG00000047410
Uniprot IDs		P42858	P12270
PDB IDs		2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O 6YEJ 7DXJ 7DXK 8R2O 8SAH 8VLX 8W15	5TO5 5TO6 5TO7 5TVB
Enriched GO Terms of Interacting Partners?		Protein Binding Cellular Response To Stress Nucleoplasm Nucleus Identical Protein Binding Positive Regulation Of Cellular Component Biogenesis Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Cellular Component Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Positive Regulation Of Organelle Organization Interleukin-18-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-translational Protein Modification Transcription Coregulator Activity Regulation Of Cellular Response To Stress Protein-containing Complex Positive Regulation Of Metabolic Process	Nuclear Pore Nuclear Basket Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Intracellular Transport Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nucleoplasm Regulation Of Nucleocytoplasmic Transport Cellular Response To Nutrient Levels Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Cellular Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Catabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Pore Complex Assembly Protein Localization To Organelle Negative Regulation Of Metabolic Process Transcription-coupled Nucleotide-excision Repair P53 Binding Regulation Of Proteasomal Protein Catabolic Process Nuclear Inclusion Body Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Nuclear Envelope Insulin Receptor Signaling Pathway Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Metaphase Plate Congression Response To UV-C Nuclear Pore Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Regulation Of Cell Cycle MAPK Cascade Nucleus Organization Positive Regulation Of Intracellular Protein Transport
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