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HTT and AP2A2
Number of citations of the paper that reports this interaction (PMID
9700202
)
73
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
HTT
AP2A2
Gene Name
huntingtin
adaptor-related protein complex 2, alpha 2 subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagic Vacuole
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Protein Complex
Cytosol
Plasma Membrane
Cytoplasmic Membrane-bounded Vesicle
AP-2 Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
P53 Binding
Protein Binding
Transcription Factor Binding
Dynactin Binding
Identical Protein Binding
Ion Channel Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Diazepam Binding
Molecular_function
Protein Binding
Lipid Binding
Protein Transporter Activity
Protein Kinase Binding
Clathrin Adaptor Activity
Biological Process
Urea Cycle
Citrulline Metabolic Process
Establishment Of Mitotic Spindle Orientation
Protein Import Into Nucleus
ER To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To ER
Endoplasmic Reticulum Organization
Golgi Organization
Dopamine Receptor Signaling Pathway
Spermatogenesis
Cell Aging
Grooming Behavior
Locomotory Behavior
Axon Cargo Transport
Determination Of Adult Lifespan
Visual Learning
Anterior/posterior Pattern Specification
Endosomal Transport
Lactate Biosynthetic Process From Pyruvate
Quinolinate Biosynthetic Process
Striatum Development
Olfactory Lobe Development
Neural Plate Formation
Insulin Secretion
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of Protein Phosphatase Type 2A Activity
Social Behavior
Hormone Metabolic Process
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Vesicle Transport Along Microtubule
Regulation Of Synaptic Plasticity
Paraxial Mesoderm Formation
Organ Development
Neuron Development
Neuron Apoptotic Process
Response To Calcium Ion
Regulation Of Mitochondrial Membrane Potential
L-glutamate Import
Iron Ion Homeostasis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Intracellular Protein Transport
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Axon Guidance
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Clathrin-mediated Endocytosis
Pathways
Retrograde neurotrophin signalling
Axon guidance
HIV Infection
Nef Mediated CD8 Down-regulation
L1CAM interactions
Signaling by Wnt
Signaling by EGFRvIII in Cancer
Recycling pathway of L1
EPH-ephrin mediated repulsion of cells
MHC class II antigen presentation
EPH-Ephrin signaling
Nef Mediated CD4 Down-regulation
EGFR downregulation
Signalling by NGF
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
beta-catenin independent WNT signaling
Signaling by EGFR
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
PCP/CE pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
108 interactors:
AKT1
AMFR
AP2A2
CASP1
CASP3
CASP6
CBS
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
HAP1
HEYL
HIP1
HIP1R
HIST1H3H
HOXC11
HOXC4
HSPA8
HYPK
HYPM
IFT20
IKBKAP
IKBKB
IKBKG
ING5
KAT2B
KIAA1377
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUPL1
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
RASA1
REST
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
17 interactors:
AMPH
AP1S1
AP2B1
APP
ATM
ATR
BIN1
CLTC
DNAJC6
DNM1
EPN1
EPS15
HTT
NUMB
SHC1
SMAD1
SNAP91
Entrez ID
3064
161
HPRD ID
00883
06256
Ensembl ID
ENSG00000197386
ENSG00000183020
Uniprot IDs
P42858
O94973
PDB IDs
2D3X
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
RNA Metabolic Process
Transcription, DNA-templated
Organelle Organization
Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Aromatic Compound Metabolic Process
Regulation Of Cellular Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Growth Factor
Cellular Response To Organic Substance
Macromolecule Biosynthetic Process
Viral Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Response To Organic Substance
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Signaling
Cellular Metabolic Process
Cellular Response To Stress
Positive Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Developmental Process
Transcription From RNA Polymerase II Promoter
Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Cell Communication
Regulation Of Transcription From RNA Polymerase II Promoter
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Vesicle-mediated Transport
Endocytosis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Post-Golgi Vesicle-mediated Transport
Golgi Vesicle Transport
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Signaling
Cell Communication
Neuron Apoptotic Process
Anatomical Structure Morphogenesis
Neuron Death
Transport
Cell Aging
Membrane Organization
Replicative Senescence
Enzyme Linked Receptor Protein Signaling Pathway
Cell Differentiation
Establishment Of Localization In Cell
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Regulation Of Clathrin-mediated Endocytosis
Regulation Of Signal Transduction
Developmental Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Intracellular Transport
Generation Of Neurons
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Positive Regulation Of Signal Transduction By P53 Class Mediator
Multicellular Organismal Development
Nervous System Development
Regulation Of Receptor Activity
Neurogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Signaling
Cellular Response To Gamma Radiation
Anatomical Structure Development
Regulation Of Neurogenesis
Receptor-mediated Endocytosis
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Protein Localization To Plasma Membrane
Cellular Localization
Cell Morphogenesis Involved In Differentiation
Learning
Notch Signaling Pathway
Cell Development
Axon Guidance
Tagcloud
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Difference)
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Intersection)
?