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HTT and HIST1H3H
Number of citations of the paper that reports this interaction (PMID
23275563
)
1
Data Source:
BioGRID
(two hybrid)
HTT
HIST1H3H
Gene Name
huntingtin
histone cluster 1, H3h
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagic Vacuole
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Protein Complex
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
P53 Binding
Protein Binding
Transcription Factor Binding
Dynactin Binding
Identical Protein Binding
Ion Channel Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Diazepam Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Urea Cycle
Citrulline Metabolic Process
Establishment Of Mitotic Spindle Orientation
Protein Import Into Nucleus
ER To Golgi Vesicle-mediated Transport
Retrograde Vesicle-mediated Transport, Golgi To ER
Endoplasmic Reticulum Organization
Golgi Organization
Dopamine Receptor Signaling Pathway
Spermatogenesis
Cell Aging
Grooming Behavior
Locomotory Behavior
Axon Cargo Transport
Determination Of Adult Lifespan
Visual Learning
Anterior/posterior Pattern Specification
Endosomal Transport
Lactate Biosynthetic Process From Pyruvate
Quinolinate Biosynthetic Process
Striatum Development
Olfactory Lobe Development
Neural Plate Formation
Insulin Secretion
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of Protein Phosphatase Type 2A Activity
Social Behavior
Hormone Metabolic Process
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Vesicle Transport Along Microtubule
Regulation Of Synaptic Plasticity
Paraxial Mesoderm Formation
Organ Development
Neuron Development
Neuron Apoptotic Process
Response To Calcium Ion
Regulation Of Mitochondrial Membrane Potential
L-glutamate Import
Iron Ion Homeostasis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Chromatin Silencing At RDNA
Chromatin Organization
DNA Replication-dependent Nucleosome Assembly
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
108 interactors:
AKT1
AMFR
AP2A2
CASP1
CASP3
CASP6
CBS
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
HAP1
HEYL
HIP1
HIP1R
HIST1H3H
HOXC11
HOXC4
HSPA8
HYPK
HYPM
IFT20
IKBKAP
IKBKB
IKBKG
ING5
KAT2B
KIAA1377
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUPL1
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
RASA1
REST
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
5 interactors:
HTT
NASP
PHF1
TRIM24
ZDHHC17
Entrez ID
3064
8357
HPRD ID
00883
11912
Ensembl ID
ENSG00000197386
ENSG00000203813
Uniprot IDs
P42858
P68431
PDB IDs
2D3X
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
1CS9
1CT6
1Q3L
2B2T
2B2U
2B2V
2B2W
2C1J
2C1N
2CV5
2KWJ
2KWK
2L75
2LBM
2M0O
2RI7
2UXN
3A1B
3AFA
3AVR
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3B95
3KMT
3KQI
3LQI
3LQJ
3O34
3O35
3O37
3RIG
3RIY
3U4S
3U5N
3U5O
3U5P
3UEE
3UEF
3UIG
3UII
3UIK
3V43
3W96
3W97
3W98
3W99
3ZG6
3ZVY
4A0J
4A0N
4A7J
4BD3
4F4U
4F56
4FWF
4HON
4I51
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cellular Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
RNA Metabolic Process
Transcription, DNA-templated
Organelle Organization
Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Aromatic Compound Metabolic Process
Regulation Of Cellular Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Response To Growth Factor
Cellular Response To Organic Substance
Macromolecule Biosynthetic Process
Viral Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Response To Organic Substance
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Signaling
Cellular Metabolic Process
Cellular Response To Stress
Positive Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Developmental Process
Transcription From RNA Polymerase II Promoter
Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Cell Communication
Regulation Of Transcription From RNA Polymerase II Promoter
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Neural Plate Formation
Biosynthetic Process
Serotonin Uptake
Lactate Biosynthetic Process From Pyruvate
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation
Regulation Of Protein Phosphatase Type 2A Activity
Response To Estrogen
Quinolinate Biosynthetic Process
Negative Regulation Of Synaptic Transmission, Dopaminergic
Negative Regulation Of Histone H3-K27 Methylation
Lactate Biosynthetic Process
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Regulation Of Vitamin D Receptor Signaling Pathway
Paraxial Mesoderm Formation
Quinolinate Metabolic Process
Cellular Response To CGMP
Response To CGMP
Serotonin Transport
Sperm Ejaculation
Neural Plate Morphogenesis
L-glutamate Import
DNA Replication-dependent Nucleosome Assembly
Protein Transport
Establishment Of Protein Localization
Citrulline Metabolic Process
Lactate Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Histone H3-K27 Methylation
Macromolecule Biosynthetic Process
Urea Cycle
Neurotransmitter Uptake
Cellular Response To Organic Cyclic Compound
Urea Metabolic Process
Regulation Of Histone H3-K27 Methylation
Cellular Response To Lipid
Thalamus Development
Striatum Development
Paraxial Mesoderm Morphogenesis
Neural Plate Development
Amino Acid Import
Regulation Of Intracellular Signal Transduction
Insemination
Metal Ion Homeostasis
Regulation Of Synaptic Transmission, Dopaminergic
Response To Steroid Hormone
Negative Regulation Of Histone Methylation
Determination Of Adult Lifespan
Grooming Behavior
Lipoprotein Transport
Tagcloud
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Difference)
?
1s
2a
3s
4c
4r
9r
aryl
carbomethoxy
carboxylic
dat
esters
ethylene
flattened
fluorophenyl
isomers
methylenedioxy
nortropane
paroxetine
phenoxy
piperidine
possesses
pseudoequatorial
reuptake
serotonin
ssri
stereochemistry
substituent
substituents
win
Tagcloud (Intersection)
?