HIST1H1C and NSD1

Number of citations of the paper that reports this interaction (PMID 24412544)
0

Data Source:
BioGRID (enzymatic study)

		HIST1H1C	NSD1
Gene Name		histone cluster 1, H1c	nuclear receptor binding SET domain protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nuclear Euchromatin	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		29 interactors: AEBP2 ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 RBX1 VHL WDR12 WDR5 YBX1	27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496
Entrez ID		3006	64324
HPRD ID		07514	09455
Ensembl ID		ENSG00000187837	ENSG00000165671
Uniprot IDs		P16403	Q96L73 Q96MN8
PDB IDs			3OOI
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Protein Monoubiquitination Histone Monoubiquitination Positive Regulation Of Gene Expression Chromosome Organization Chromatin Modification Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H2B Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Endodermal Cell Differentiation Stem Cell Maintenance Histone Modification Negative Regulation Of Myeloid Cell Differentiation Histone Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Stem Cell Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Wnt Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Endoderm Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Stem Cell Differentiation Gastrulation Regulation Of Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation RNA Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development
Tagcloud ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Difference) ?		allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2	abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Intersection) ?